Status of antioxidant and homocysteine-lowering vitamins related to cardiovascular diseases in hemodialysis patients

Abstract

Background and aimCardiovascular disease is the major cause of mortality in hemodialysis patients. Oxidative stress and hyperhomocysteinemia may contribute to an increased risk of CVD. Therefore, we assessed the status of antioxidant and homocysteine-lowering vitamins related to cardiovascular disease in hemodialysis patients at Vasei hospital in Sabzevar.MethodsIn this cross-sectional study, we enrolled 75 hemodialysis patients by using census method at Vasei Hospital in Sabzevar (Iran) in 2014. After measuring height and body weight, food intake was assessed by a 24-hour dietary recall questionnaire for at least two days (a non-dialysis and dialysis day), and food frequency was recorded with Nutritionist IV software. Data were analyzed by SPSS version 16, using descriptive statistical tests, one sample t-test and independent samples t-test and p<0.05 was considered statistically significant.ResultsThis study was carried out on 75 patients. Mean age and BMI of patients were 49.95±17.22 years and 20.04±3.38 kg/m2, respectively. Intake of all vitamins with the exception of vitamin B12 in hemodialysis patients studied, were less than the recommended dietary allowance (RDA) (p<0.05).ConclusionAccording to the survey, consumption of antioxidants and B-vitamins related to cardiovascular disease was less than RDA in hemodialysis patients.

Study of homocysteine and its correlation with biochemical parameters in patients with chronic renal failure

“…Table (1) and Figure (1) show a significant increase in the concentration of serum homocysteine patients group in comparison with control group (p < 0.05 ). There were also previous study reporting an increase in the homocysteine concentration in hemodialysis patients [2], [4], [5]. Homocysteine is degraded in the body through two metabolic pathways, while a minor part is excreted through kidneys.…”