Status epilepticus in pregnancy: a literature review and a protocol proposal

Roberti, Roberta; Rocca, Morena; Iannone, Luigi Francesco; Gasparini, Sara; Pascarella, Angelo; Neri, Sabrina; Cianci, Vittoria; Bilo, Leonilda; Russo, Emilio; Quaresima, Paola; Aguglia, Umberto; Carlo, Costantino Di; Ferlazzo, Edoardo

doi:10.1080/14737175.2022.2057224

Cited by 15 publications

(16 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress, on the other hand, may have a role in anisocytosis and elevated RDW [27]. Both inflammatory process and oxidative stress are characteristics of pre-eclampsia, which may explain the higher levels of RDW in severe pre-eclampsia [1,2,4].…”

Section: Discussionmentioning

confidence: 99%

“…Pre-eclampsia was defined based on the American College guidelines and involved cases admitted to the hospital and fulfilled the diagnostic criteria of pre-eclampsia, blood pressure equal to or over 140/90 mm/Hg on two occasions six hours apart with proteinuria 300mg/dl or more per day. Features of severe PE include blood pressure >=160/110 mmHg, accompanied by one or more of proteinuria ≥ 500 mg per day, oliguria less than 500 ml per 24 h, impaired hepatic function, pulmonary edema or cyanosis, epigastric or right-upper abdominal pain, cerebral or visual disturbance, and fetal growth restriction, and thrombocytopenia [1,14].…”

Section: Study Parameters and Workflowmentioning

confidence: 99%

“…It almost always causes adverse effects for the pregnant and her unborn neonate. [1]. PE is defined by the development of hypertension beyond 20 weeks of gestation in pregnant who previously did not have hypertension with or without albuminuria or hypertension that causes end organ failure [2].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The capacity of RDW and Platelet indices in defining pre-eclampsia severity: a cases-control study

Nori¹,

Hussein²,

Salman³

et al. 2023

It Journ Gyn Obs

View full text Add to dashboard Cite

Objective. Pre-eclampsia (PE) is a peculiar pregnancy complication with adverse feto-maternal outcomes. Red blood cell distribution width (RDW) and platelet indices are complete blood count parameters; tested as a marker for cardiovascular diseases. The inflammatory theory was proposed for PE etiology; therefore, we aimed to investigate the role of RDW and platelet parameters in determining preeclampsia severity.Patients and methods. At Al-Yarmouk Hospital, we conducted a case-control study. 120 pregnant women satisfied inclusion criteria, divided into two groups. According to American guidelines, PE cases (60/120) and healthy controls (60/120).PE cases were subdivided into severe PE (34/60) and non-severe PE (26/60) cases. A blood sample was aspirated for complete blood count, including RDW, mean platelet volume (MPV), and platelet distribution width (PDW).Results. RDW and MPV were meaningfully higher in PE cases than controls, with a P-value of 0.003 and 0.004, respectively. A significant difference was found in the RDW and PDW in subgroups analysis of severe vs. non-severe PE cases, with Pvalues of 0.001 and 0.037, respectively. Only RDW was significantly correlated with systolic BP; r = 0.47. and diastolic BP; r = 0.399. At a cutoff value of > 15.6%, RDW showed 56.7 %sensitivity and 95.8 % specificity, P < 0.001, distinguishing severe from non-severe PE pregnancies.Conclusions. RDW discriminated PE severity with good accuracy and preceded platelets indices, implying its validity as a marker of severe PE. RDW is a simple, inexpensive test available in antenatal care services. Accurate diagnosis permits early focused treatment, vigorous monitoring, and timely interventions for improving pregnancy outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Study Parameters and Workflowmentioning

confidence: 99%

See 1 more Smart Citation

The capacity of RDW and Platelet indices in defining pre-eclampsia severity: a cases-control study

Nori¹,

Hussein²,

Salman³

et al. 2023

It Journ Gyn Obs

View full text Add to dashboard Cite

show abstract

“…6 If seizures are uncontrolled, we should follow the status epilepticus protocol for pregnant females. 7 The hemodynamic target varies slightly from the nonpregnant patients, including maintaining normotension (20% baseline), euvolemia, normoxia (partial pressure of oxygen > 80 mm Hg to avoid fetal hypoxia), normothermia, normocapnia in the early trimester, and normoglycemia (110-150 mg/dL) should be considered. 8 Mild hyperventilation (28-32 mm Hg) may be continued to maintain physiological hyperventilation in second and third trimester.…”

mentioning

confidence: 99%

“…6 If seizures are uncontrolled, we should follow the status epilepticus protocol for pregnant females. 7…”

mentioning

confidence: 99%

Awake Craniotomy in a Pregnant Patient—A Unique Challenge

Kaur,

Singh,

Jangra

et al. 2023

J Neuroanaesth Crit Care

View full text Add to dashboard Cite

Safety of electroconvulsive therapy (ECT) in pregnancy: a systematic review of case reports and case series

Cipolla,

Catapano,

Messina

et al. 2023

Arch Womens Ment Health

View full text Add to dashboard Cite

Pregnancy and the immediate postpartum period are considered at high risk for women who have already received a previous psychiatric diagnosis and might represent a stressful event favoring the onset of new psychiatric disorders. The electroconvulsive therapy (ECT) is effective for the treatment of severe, treatment-resistant mental disorders, and it could represent a therapeutic choice for psychiatric conditions during pregnancy. The purpose of this systematic review is to evaluate the safety of ECT during pregnancy and to update the state of the art of its use. An extensive literature search on PubMed, APA PsycInfo, and Scopus databases for relevant articles published from inception to September 2023 has been performed. A final number of 45 articles (34 case reports and 11 case series, for a total of 130 pregnant women) were included in the present review. The limited evidence confirmed that ECT is effective in determining a partial remission of symptoms in women suffering from severe mental disorders, especially in the presence of suicidal ideation or psychosis, during all pregnancy epochs. However, ECT is not free from side effects, although the majority of possible complications were of low- or moderate-grade and not life-threatening for the women. Exposure to pharmacological treatment before or during the ECT or to the anesthetic during ECT might have contributed to the onset of these complications. ECT techniques evolved over years, increasing the degree of its safety, and according to our review it appears to be relatively safe and effective during pregnancy in the majority of cases.

show abstract

Status epilepticus in pregnancy: a literature review and a protocol proposal

Cited by 15 publications

References 128 publications

The capacity of RDW and Platelet indices in defining pre-eclampsia severity: a cases-control study

The capacity of RDW and Platelet indices in defining pre-eclampsia severity: a cases-control study

Awake Craniotomy in a Pregnant Patient—A Unique Challenge

Safety of electroconvulsive therapy (ECT) in pregnancy: a systematic review of case reports and case series

Contact Info

Product

Resources

About