Status Epilepticus: A Clinical and Pathological Study in Epilepsy

Clark, L. Pierce; Prout, Thomas P.

doi:10.1176/ajp.61.1.81

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many other reports followed, culminating with the definitive clinical and pathologic descriptions of status epilepticus that were provided by Clark andProut in 1903 and1904 (5). Another …”

Section: Historymentioning

confidence: 99%

“…In papers published in the late 1800s and early 1900s, Clark and Prout defined status epilepticus as the maximal development of epilepsy, in which seizures are so frequent that "the coma and exhaustion are continuous between the seizures" (5). This was very similar to the definition used by Wilson almost 40 years later, in which status epilepticus was defined as seizures in which "the post-convulsive sleep of one attack is cut short by development of the next" (6).…”

Section: What Is the Definition Of Status Epilepticus?mentioning

confidence: 99%

See 1 more Smart Citation

Status Epilepticus: An Overview of the Clinical Problem

Lowenstein

1999

Epilepsia

145

View full text Add to dashboard Cite

Summary: Status epilepticus has been recognized since antiquity. The terms état de mal and “status epilepticus” are derived from the slang used by epilepsy patients housed in Salpêtrière and Bicêtre hospitals in Paris during the 1800s. The definition of status epilepticus has been evolving, and is still not precise. In 1903–04 it was described as a development of epilepsy in which seizures are so frequent that “coma and exhaustion are continuous between seizures.” In 1964 the International League Against Epilepsy adopted the definition “a seizure [that] persists for a sufficient length of time or is repeated frequently enough to produce a fixed and enduring epileptic condition.” 30 min has been the most common specified duration of seizures for the diagnosis of status epilepticus, although a duration of 10 or 20 min has been suggested as well. However, a new set of definitions for generalized, convulsive status epilepticus in adults has been proposed and includes an operational definition (specifying a seizure duration of a least 5 min) and a mechanistic definition. In the future, laboratory tests will provide the means for detecting and defining the critical factors that distinguish a single epileptic seizure from status epilepticus. Recent epidemiological studies suggest status epilepticus occurs in 100,000 to 150,000 people in the US each year, and is associated with substantial morbidity and mortality. Etiology, duration of the seizures, and the patient's age seem to be important determinants of the outcome in status epilepticus.

show abstract

“…Many other reports followed, culminating with the definitive clinical and pathologic descriptions of status epilepticus that were provided by Clark andProut in 1903 and1904 (5). Another …”

Section: Historymentioning

confidence: 99%

Section: What Is the Definition Of Status Epilepticus?mentioning

confidence: 99%

Status Epilepticus: An Overview of the Clinical Problem

Lowenstein

1999

Epilepsia

145

View full text Add to dashboard Cite

show abstract

“…The clinical progression of SE consists of four stages [34][35][36]. The early stage of SE begins when continuous seizure activity exceeds five minutes after the treatment with benzodiazepines [4].…”

Section: Status Epilepticusmentioning

confidence: 99%

Treating Status Epilepticus: Phenytoin Versus Levetiracetam

Dell'Aquila

Soti

2021

Cureus

View full text Add to dashboard Cite

For decades, phenytoin has been the drug of choice for the treatment of epilepsy but also the second-line treatment for status epilepticus (SE). However, newer antiepileptic drugs (AEDs) have emerged as safer alternatives for the suppression of seizures. Consequently, phenytoin has recently fallen under scrutiny in the research world, prompting many studies to compare its efficacy to these other drugs, most notably levetiracetam. Levetiracetam is a second-generation AED, which is gaining wide clinical use as the second-line agent in treating SE patients. This review focuses on several clinical studies that have directly compared the effectiveness of phenytoin and levetiracetam in suppressing SE seizure activity. Additionally, this review highlights several advantages of using levetiracetam over phenytoin in this clinical context.

show abstract