Status Epilepticus: A Clinical and Pathological Study in Epilepsy

Clark, L. Pierce; Prout, Thomas P.

doi:10.1176/ajp.60.4.645

Cited by 14 publications

(24 citation statements)

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“…Upon recovery he was profoundly demented and died 12 months later. Postmortem examination showed widespread damage, particularly in the temporal lobe and hippocampus, underlying the destructive nature of prolonged status epilepticus as previously discussed by Clark and Prout, (1903/4). A further case of a boy who developed status epilepticus 24 h after a trivial head injury and died, showed widespread but asymmetrical damage typical of anoxic damage.…”

Section: –1969: Status Epilepticus In the First 50 Years Of The Isupporting

confidence: 62%

“…Clark was a physician and Prout a pathologist in Craig Colony, an asylum in Sonyea in New York State. In these papers, a definitive and meticulous clinical and pathologic description of tonic–clonic status epilepticus is given (Clark & Prout, 1903/4). Their work was based on the study of 38 cases of status epilepticus, five cases of serial seizures or état mal de passage and four cases of status hystericus from the asylum.…”

Section: The Concept and Clinical Features Of Status Epilepticus: Prementioning

confidence: 99%

“…The section in his book devoted to status epilepticus (4 of 270 pages) sums up very succinctly knowledge at the time, and in many ways the basic conclusions he draws about clinical features, causes, and outcome are very similar to those of today. He cites the definition of Clark and Prout (Clark & Prout, 1903/4) of status epilepticus as the maximum development of epilepsy . He commented that although many epileptics never develop status epilepticus, it is undoubtedly more common than generally supposed.…”

Section: The Concept and Clinical Features Of Status Epilepticus: Prementioning

confidence: 99%

“…They warn that only the minimum amount of sedation as is necessary to control the fits should be used. In the comatose period, the aim of treatment was to counteract the exhaustion and sedation of the convulsive period and to monitor for a possible return of seizures (Clark & Prout, 1903/4).…”

Section: Treatment Of Status Epilepticusmentioning

confidence: 99%

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The history of status epilepticus and its treatment

Neligan

Shorvon

2009

Epilepsia

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SUMMARYDespite the fact that status epilepticus was been recognized since antiquity, its existence was largely ignored until the mid-nineteenth century. In this review we cover the medical literature of status epilepticus from the late nineteenth century until the early 1970s when the modern era of status epilepticus began. We pay particular attention to the impact of the ILAE and its principal members on the understanding and awareness of status epilepticus. We also cover the evolution of treatment regimens advocated for status epilepticus from the late nineteenth century to the early 1970s when the benzodiazepines were established as first line treatments.

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Section: –1969: Status Epilepticus In the First 50 Years Of The Isupporting

confidence: 62%

Section: The Concept and Clinical Features Of Status Epilepticus: Prementioning

confidence: 99%

Section: The Concept and Clinical Features Of Status Epilepticus: Prementioning

confidence: 99%

Section: Treatment Of Status Epilepticusmentioning

confidence: 99%

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The history of status epilepticus and its treatment

Neligan

Shorvon

2009

Epilepsia

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“…Clark and Prout’s (1903) description of three sequential phases of SE is still valid. We call these phases impending SE, established SE, and subtle SE (Chen & Wasterlain, 2006; Wasterlain & Chen, 2006).…”

Section: Basic Concepts and Therapeutic Principlesmentioning

confidence: 99%

Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs

2008

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SUMMARYWe review recent advances in our understanding and treatment of status epilepticus (SE). Repeated seizures cause an internalization of c-aminobutyric acid (GABA) A receptors, together with a movement of N-methyl-D-aspartate (NMDA) receptors to the synapse. As a result, the response of experimental SE to treatment with GABAergic drugs (but not with NMDA antagonists) fades with increasing seizure duration. Prehospital treatment, which acts before these changes are established, is finding increased acceptance, and solid evidence of its efficacy is available, particularly in children. Rational polypharmacy aims at multiple receptors or ion channels to increase inhibition and simultaneously reduce excitation. Combining GABA A agonists with NMDA antagonists and with agents acting at other sites is successful in treating experimental SE, and in reducing SEinduced brain damage and epileptogenesis. The relevance of these experimental data to clinical SE is actively debated. Valproate and levetiracetam have recently become available for intravenous use, and the use of ketamine and of other agents (topiramate, felbamate, etc.) have seen renewed interest. A rapidly increasing but largely anecdotal body of literature reports success in seizure control at the price of relatively few complications with the clinical use of those agents in refractory SE.

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The enigmatic figure of Leon Pierce Clark and his contribution to epilepsy

Shorvon

2022

Epilepsia Open

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Leon Pierce Clark (1870‐1933) was a prominent American neurologist and psychiatrist and an enigmatic figure. He made enduring contributions to status epilepticus and to epilepsy. In the 1910s and 1920s, his chief focus was on the psychological mechanisms of epilepsy and on the personality of those with idiopathic epilepsy which he interpreted from a psychoanalytical perspective. He also described the epileptic voice sign, wrote psychobiographies of among others Abraham Lincoln and Napoleon Bonaparte, and published a book of poetry. He held many important positions in American professional societies and yet was embroiled in controversy.

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Status Epilepticus: A Clinical and Pathological Study in Epilepsy

Cited by 14 publications

References 0 publications

The history of status epilepticus and its treatment

The history of status epilepticus and its treatment

Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs

The enigmatic figure of Leon Pierce Clark and his contribution to epilepsy

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