Status check: biocatalysis; its use with and without chemocatalysis. How does the fine chemicals industry view this area?

Gallou, Fabrice; Gröger, Harald; Lipshutz, Bruce H.

doi:10.1039/d3gc01931d

Cited by 11 publications

(10 citation statements)

References 58 publications

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“…Water has excellent potential as a solvent for both chemo- and biocatalysis. , Micelles can help promote this potential. Despite demonstrating the usefulness of chemo- and biocatalysts in one-pot processes, two significant challenges have recently been addressed. ,, First, enhancing the mass transfer of hydrophobic substrates to the micelle has improved the process efficiency.…”

Section: Design and Applications Of Ps-750-mmentioning

confidence: 99%

Aqueous Micelles as Solvent, Ligand, and Reaction Promoter in Catalysis

Virdi,

Dusunge,

Handa

2024

JACS Au

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Water is considered to be the most sustainable and safest solvent. Micellar catalysis is a significant contributor to the chemistry in water. It promotes pathways involving water-sensitive intermediates and transient catalytic species under micelles' shielding effect while also replacing costly ligands and dipolar-aprotic solvents. However, there is a lack of critical information about micellar catalysis. This includes why it works better than traditional catalysis in organic solvents, why specific rules in micellar catalysis differ from those of conventional catalysis, and how the limitations of micellar catalysis can be addressed in the future. This Perspective aims to highlight the current gaps in our understanding of micellar catalysis and provide an analysis of designer surfactants' origin and essential components. This will also provide a fundamental understanding of micellar catalysis, including how aqueous micelles can simultaneously perform multiple functions such as solvent, ligand, and reaction promoter.

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Section: Design and Applications Of Ps-750-mmentioning

confidence: 99%

Aqueous Micelles as Solvent, Ligand, and Reaction Promoter in Catalysis

Virdi,

Dusunge,

Handa

2024

JACS Au

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“…[84] Biocatalysis A creative method for producing molecules with complicated structural makeup and several stereogenic centers is biocatalysis. [85] In contrast to the traditional chemical synthesis approach, it may be carried out safely and enantiomeric excess is the primary need to thrive. Because of their great selectivity, high activity under moderate reaction conditions, biodegradability, and non-toxicity, biocatalysts exhibit a number of benefits in the creation of chiral intermediates for the fabrication of homochiral medicines.…”

Section: Organometallic Catalysismentioning

confidence: 99%

“…A creative method for producing molecules with complicated structural makeup and several stereogenic centers is biocatalysis [85] . In contrast to the traditional chemical synthesis approach, it may be carried out safely and enantiomeric excess is the primary need to thrive.…”

Section: Biocatalysismentioning

confidence: 99%

Enantioselective Synthesis of Flavonoids and Their Diverse Applications in Nutrition, Health, and Medicine: A Mini Review

Qayyum,

Shahid,

Mansoor

et al. 2024

ChemistrySelect

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Enantioselective synthesis, which yields one enantiomer in higher concentration or purity than the other, has transformed the production of flavonoids. Flavonoids, which are found in large quantities in nature and are known to exhibit a diverse array of physiological activities, are an ideal choice for enantioselective synthesis due to the significance of chirality in their therapeutic effects. Enantioselective synthesis is used in the medicinal, nutraceutical, and agrochemical sectors to produce flavonoids, which are useful in the development of novel therapeutics with improved effectiveness and fewer adverse reactions. The ability to obtain specific enantiomers of flavonoids facilitates the elucidation of biochemical strategies and the relationship between structure and activity, thereby providing avenues for tailored drug design and optimization. This review highlights the critical role that enantioselective synthesis plays in achieving the full potential of flavonoids for a variety of therapeutic and non‐therapeutic applications. It also discusses the challenges and prospects of enantioselective syntheses to create relevant classes of flavonoid monomers, emphasizing their applications in the field. The review focused on the synthetic methods for fabricating native flavonoids and their analogs, highlighting the critical role that enantioselective synthesis of flavonoids plays in maximizing their therapeutic potential for enhancing human health and wellbeing.

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“…Different biocatalytic methods have been developed for the production of the statin side chain all with high enantiomeric excess. 3,5–8 The biocatalytic aldol reaction catalysed by 2-deoxyribose-5-phosphate aldolase (DERA, EC: 4.1.2.4) has become one of the most attractive routes for the highly stereoselective synthesis of the statin side chain precursor from the inexpensive starting material acetaldehyde (Scheme 1). 3,9,10 Although the synthesis of the side chain precursor catalysed by DERA has been well characterised, it remains challenging, because of the instability of the enzyme under reaction conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the oxidation of initially formed lactol (formed in the DERA catalysed stage) to the lactone that is incorporated into the statins is often performed chemically. 8,11,12 Enzymatic oxidation of the lactol to lactone is a promising step due to the mild reaction conditions with a major selectivity challenge: 13–15 the hydroxyl group of the hemiacetal has to be selectively oxidised in the presence of the 3( R )-hydroxyl group. The same problem arises for the oxidation of lactol 3 to δ-lactone 4 , this study's model compound.…”

Section: Introductionmentioning

confidence: 99%