“…SNRIs are advantageous over tricyclic antidepressants because, unlike the latter, they do not block muscarinic cholinergic, H 1 histaminergic, nor α1-adrenergic receptors, thereby resulting in fewer side effects (Dauvilliers et al, 2014b; Guilleminault and Cao, 2011). However, similar to tricyclic antidepressants, SNRIs are associated with an increase in the number and severity of cataplexy attacks after withdrawal, even with gradual tapering of the drugs (Ristanovic et al, 2009; Wang and Greenberg, 2013). Antidepressants have also been linked to the development of REM behavior disorder (Ju et al, 2011), although it is not clear if narcolepsy predisposes for this risk.…”