Status and prospect of novel treatment options toward alveolar and cystic echinococcosis

Wang, Sibo; Ying, Ma; Wang, Weishan; Dai, Yi; Sun, Haohao; Li, Jing; Wang, Shan; Li, Feng

doi:10.1016/j.actatropica.2021.106252

Cited by 21 publications

(14 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the next step, the active compounds could be tested in vivo. The murine model of cystic echinococcosis gives a more realistic approach to the study of antiparasitic drugs compared with in vitro experiments [ 8 ]. Like all experimental animal models, the murine model of cystic echinococcosis has advantages and disadvantages.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, hepatotoxicity, alopecia, gastrointestinal disturbances, thrombocytopenia, and severe leukopenia have been reported, and these cases require stopping the prescribed treatment [ 7 ]. New alternative treatments are urgently required based on pharmacological evidence and the relatively low and slow efficacy of ABZ [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Albani

Borgo

Fabbri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Cystic echinococcosis is a zoonotic disease caused by the parasite Echinococcus granulosus sensu lato (s.l.), which is worldwide distributed and causes long-lasting infections in animals and humans. The existing treatment is limited to the use of benzimidazoles, mainly albendazole (ABZ). However, it has unwanted side effects and its efficacy is about 50%. The Asteraceae family includes plants that have therapeutic applications (medicinal species) and has an important role in new drug development. The species belonging to a different genus of this family show a wide range of anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, and antiparasitic activities, among others. The aim of the present study was to evaluate the in vitro efficacy of extracts of four Asteraceae species against protoscoleces of E. granulosus sensu stricto (s.s.). On the other hand, the Stevia aristata extract was assessed on the murine cyst of E. granulosus (s.s.) and the efficacy of S. aristata extract was investigated in a murine model of CE. Stevia satureiifolia, S. aristata, Grindelia pulchella, and G. chiloensis extracts at 100 μg/mL caused a decrease in protoscoleces viability; however, S. aristata extract produced the greatest in vitro protoscolicidal effect. After 20 days of treatment with the highest concentration (100 μg/mL) of S. aristata extract, protoscoleces viability decreased to 0%. The tegumental changes observed by scanning electron microscopy were consistent with the reduction in vitality. The collapse of the germinal layer was registered in 60 ± 5.8% and 83.3 ± 12.0% of cysts treated during 4 days with 50 and 100 μg/ml, respectively. The half maximal effective concentration (EC50) value of the S. aristata extract against E. granulosus (s.s.) cysts was 47.86 μg/mL (96 h). The dosage of infected animals with the 50 mg kg−1 dose of S. aristata extract resulted in a significant reduction in cyst weight in comparison with the control group. In conclusion, S. aristata extract was demonstrated to exert a marked effect, both in vitro and in the murine model.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Albani

Borgo

Fabbri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Currently, there are three therapeutic strategies for hepatic CE: surgery, ultrasound-guided aspiration, and chemotherapy [ 33 , 34 ]. Watch and wait strategy is usually implemented in case of inactive, asymptomatic cysts.…”

Section: Discussionmentioning

confidence: 99%

Basic Operative Tactics for Pulmonary Echinococcosis in the Era of Endostaplers and Energy Devices

et al. 2023

View full text Add to dashboard Cite

Human echinococcosis is a zoonotic infection caused by the larvae of the tapeworm species Echinococcus. The liver is the most common location for a primary echinococcosis. However, the parasite may bypass or spread from the liver to the lungs, causing primary or secondary pulmonary echinococcosis, respectively. Pulmonary echinococcosis is a clinically challenging condition in which anthelminthic regiments are important, but surgery has the central role in removing the cysts and preventing recurrences. Surgical treatment may involve cystotomy, enucleation, capitonnage, or atypical resections, which occasionally are in combination with hepatic procedures. The utilization of modern devices is greatly underdescribed in surgery for thoracic infections, even though these facilitate much of the work. Therefore, this article aims to describe pulmonary echinococcosis and the role of modern surgical devices in the treatment process. Furthermore, we report surgical treatment of three different cases of pulmonary echinococcosis. Surgeries of uncomplicated and ruptured hepatic or pulmonary cysts are described. Simple small pulmonary echinococcal lesions can be excised by endostaplers both for diagnostic and curative reasons. Larger cysts can be removed by energy devices unless large bronchial air leaks occur. Complicated cysts require treatment by more extensive techniques. Inexperienced surgeons should not abstain but should carefully decide preoperatively how to proceed.

show abstract

“…The main treatment strategies for AE are surgery and anti-echinococcal drugs, such as albendazole (ABZ) and mebendazole (MBZ) ( Craig et al, 2007 ; Gottstein et al, 2015 ; Wang S. et al, 2021 ; Huang et al, 2021 ). However, both strategies have limitations.…”

Section: Introductionmentioning

confidence: 99%

Integrative Analysis of RNA Expression and Regulatory Networks in Mice Liver Infected by Echinococcus multilocularis

Liu

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

The larvae of Echinococcus multilocularis causes alveolar echinococcosis, which poses a great threat to the public health. However, the molecular mechanisms underlying the host and parasite interactions are still unclear. Exploring the transcriptomic maps of mRNA, miRNA and lncRNA expressed in the liver in response to E. multilocularis infection will help us to understand its pathogenesis. Using liver perfusion, different cell populations including the hepatic cells, hepatic stellate cells and Kupffer cells were isolated from mice interperitoneally inoculated with protoscoleces. Their transcriptional profiles including lncRNAs, miRNAs and mRNAs were done by RNA-seq. Among these cell populations, the most differentially-expressed (DE) mRNA, lncRNAs and miRNAs were annotated and may involve in the pathological processes, mainly including metabolic disorders, immune responses and liver fibrosis. Following the integrative analysis of 38 differentially-expressed DEmiRNAs and 8 DElncRNAs, the lncRNA-mRNA-miRNA networks were constructed, including F63-miR-223-3p-Fbxw7/ZFP36/map1b, F63-miR-27-5p-Tdrd6/Dip2c/Wdfy4 and IFNgAS1-IFN-γ. These results unveil the presence of several potential lncRNA-mRNA-miRNA axes during E. multilocularis infection, and further exploring of these axes may contribute to better understanding of the pathogenic mechanisms.

show abstract

Status and prospect of novel treatment options toward alveolar and cystic echinococcosis

Cited by 21 publications

References 176 publications

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Basic Operative Tactics for Pulmonary Echinococcosis in the Era of Endostaplers and Energy Devices

Integrative Analysis of RNA Expression and Regulatory Networks in Mice Liver Infected by Echinococcus multilocularis

Contact Info

Product

Resources

About