Stature of young people with malignant bone tumors

Cotterill, SJ; Wright, Charlotte; Pearce, Mark S.; Craft, Alan

doi:10.1002/pbc.10437

Cited by 106 publications

(84 citation statements)

References 18 publications

(21 reference statements)

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“…To mitigate this possibility we included a wide variety of diagnoses in the control group. Finally, the relatively small number of cases limited statistical power, however, owing to the rarity of this tumour, our study includes more cases than all but one of previously published studies (Cotterill et al, 2004). Larger studies, however, are needed, particularly to investigate subgroup risks.…”

Section: Discussionmentioning

confidence: 99%

“…There is some evidence (Fraumeni 1967;Gelberg et al, 1997;Cotterill et al, 2004) of cases being taller than controls, although the differences often derive from inconsistent subgroup findings defined by age, gender, or anatomic site. Other data suggest no differences in height or average growth rate (Operskalski et al, 1987;Pui et al, 1987;Glasser et al, 1991;Buckley et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Perinatal factors, growth and development, and osteosarcoma risk

et al. 2006

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Osteosarcoma incidence patterns suggest an aetiologic role for perinatal factors, and growth and development. Osteosarcoma patients (n ¼ 158) and controls with benign orthopaedic conditions (n ¼ 141) under age 40 were recruited from US orthopaedic surgery departments. Exposures were ascertained by interview, birth, and growth records. Age-and sex-adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated. Current height and age-and sex-specific height percentiles were not associated with osteosarcoma risk. Male cases, however, appeared to have an earlier adolescent growth period, and earlier attainment of final height (OR ¼ 7.1; 95% CI ¼ 1.6 -50 for o19 vs 19 þ years), whereas earlier puberty appeared protective with ORs of 0.41 (95% CI 0.18 -0.89) and 0.68 (95% CI 0.31 -1.5) for developing facial and pubic hair, respectively. High birth weight was associated with an elevated osteosarcoma risk (OR ¼ 3.9; CI ¼ 1.7 -10 for 4000 g vs 3000 -3500 g), although there was no trend in risk with increasing weight. These data provide some evidence that osteosarcoma is related to size at birth and in early adolescence, while earlier puberty in male subjects may be protective.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Perinatal factors, growth and development, and osteosarcoma risk

et al. 2006

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“…This is a highly malignant bone tumor with its incidences more in males than in females. The tumor mostly occurs in the metaphyseal area of long bones involving the growth plate, with majority of the cases occurring in the distal femur and proximal febia (Longhi et al, 2006;Cotterill et al, 2004). Around 25% of the osteosarcoma patients have already advanced to metastatic stage at diagnosis and lungs are the most common region where the tumor migrates (Wesolowski and Budd, 2010).…”

Section: Introductionmentioning

confidence: 99%

Caryophyllene oxide exhibits anti-cancer effects in MG-63 human osteosarcoma cells via the inhibition of cell migration, generation of reactive oxygen species and induction of apoptosis

Pan

Wang

Cheng

et al. 2016

Bangladesh J Pharmacol

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The main objective of the present study was to evaluate the antitumor and apoptotic effects of caryophyllene oxide in MG-63 human osteosarcoma cells. Cell viability of these cells was evaluated by MTT assay while as in vitro wound healing assay was used to study the effect of caryophyllene oxide on cell migration. Fluorescence microscopy and transmission electron microscopy were used to study the changes in cell morphology once the cells undergo apoptosis. Caryophyllene oxide significantly led to cytotoxicity in MG-63 cells showing dose-dependent as well as time-dependent effects. Caryophyllene oxide led to an inhibition of wound closure significantly. At caryophyllene oxide doses of 20, 80 and 120 µM, the percentage of cell migration was shown to be 94.2, 67.1 and 14.8% respectively. With an increase in the caryophyllene oxide dose, the extent of apoptosis also increased characterized by cellular shrinkage, membrane blebbing, chromatin condensation and apoptotic body formation.Video Clip:<a href="https://youtube.com/v/nfnouVZou18">Cell viability assay</a>: 2 min 22 sec

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“…Although it can occur at any age, it is predominantly a disease that afflicts the young with a peak incidence in the second and third decades of life [9]. Numerous variables have been associated with an adverse prognosis in osteosarcoma including metastatic disease at presentation, nonosteoblastic histological subtype, tumor size, male gender, young age, tumor location, genetic variations, poor response to neoadjuvant chemotherapy, and inadequate surgical margins [4,7,10,12].…”

Section: Introductionmentioning

confidence: 99%

A Novel System for the Surgical Staging of Primary High-grade Osteosarcoma: The Birmingham Classification

Jeys

Thorne

Parry

et al. 2017

Clinical Orthopaedics &Amp; Related Research

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Background Chemotherapy response and surgical margins have been shown to be associated with the risk of local recurrence in patients with osteosarcoma. However, existing surgical staging systems fail to reflect the response to chemotherapy or define an appropriate safe metric distance from the tumor that will allow complete excision and closely predict the chance of disease recurrence. We therefore sought to review a group of patients with primary high-grade osteosarcoma treated with neoadjuvant chemotherapy and surgical resection and analyzed margins and chemotherapy response in terms of local recurrence. Questions/purposes (1) What predictor or combination of predictors available to the clinician can be assessed that more reliably predict the likelihood of local recurrence? (2) Can we determine a better predictor of local recurrencefree survival than the currently applied system of surgical margins? (3) Can we determine a better predictor of overall survival than the currently applied system of surgical margins? Methods This retrospective study included all patients with high-grade conventional osteosarcomas without metastasis at diagnosis treated at one center between 1997 and 2012 with preoperative chemotherapy followed by resection or amputation of the primary tumor who were younger than age 50 years with minimum 24-month followup for those still alive. A total of 389 participants matched the inclusion criteria. Univariate log-rank test and multivariate Cox analyses were undertaken to identify predictors of local recurrence-free survival (LRFS). The Birmingham classification was devised on the basis of two stems: the response to chemotherapy (good response = C 90% necrosis; poor response = \ 90% necrosis) and margins (\ 2 mm or C 2 mm). The 5-year overall survival rate was 67% (95% confidence interval [CI], 61%-71%) and 47 patients developed local recurrence (12%). Results Intralesional margins (hazard ratio [HR], 9.9; 95% CI, 1.2-82; p = 0.03 versus radical margin HR, 1) and a poor response to neoadjuvant chemotherapy (HR, 3.8; 95% CI, 1.7-8.4; p = 0.001 versus good response HR, 1) were independent risk factors for local recurrence (LR). The best predictor of LR, however, was a combination of

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Stature of young people with malignant bone tumors

Abstract: This study suggests that tall stature and an earlier pubertal growth spurt may be important factors in the aetiology of both osteosarcoma and Ewing sarcoma.

Cited by 106 publications

References 18 publications

Perinatal factors, growth and development, and osteosarcoma risk

Perinatal factors, growth and development, and osteosarcoma risk

Caryophyllene oxide exhibits anti-cancer effects in MG-63 human osteosarcoma cells via the inhibition of cell migration, generation of reactive oxygen species and induction of apoptosis

A Novel System for the Surgical Staging of Primary High-grade Osteosarcoma: The Birmingham Classification

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