2003
DOI: 10.1002/pbc.10437
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Stature of young people with malignant bone tumors

Abstract: This study suggests that tall stature and an earlier pubertal growth spurt may be important factors in the aetiology of both osteosarcoma and Ewing sarcoma.

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Cited by 106 publications
(84 citation statements)
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References 18 publications
(21 reference statements)
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“…To mitigate this possibility we included a wide variety of diagnoses in the control group. Finally, the relatively small number of cases limited statistical power, however, owing to the rarity of this tumour, our study includes more cases than all but one of previously published studies (Cotterill et al, 2004). Larger studies, however, are needed, particularly to investigate subgroup risks.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…To mitigate this possibility we included a wide variety of diagnoses in the control group. Finally, the relatively small number of cases limited statistical power, however, owing to the rarity of this tumour, our study includes more cases than all but one of previously published studies (Cotterill et al, 2004). Larger studies, however, are needed, particularly to investigate subgroup risks.…”
Section: Discussionmentioning
confidence: 99%
“…There is some evidence (Fraumeni 1967;Gelberg et al, 1997;Cotterill et al, 2004) of cases being taller than controls, although the differences often derive from inconsistent subgroup findings defined by age, gender, or anatomic site. Other data suggest no differences in height or average growth rate (Operskalski et al, 1987;Pui et al, 1987;Glasser et al, 1991;Buckley et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…This is a highly malignant bone tumor with its incidences more in males than in females. The tumor mostly occurs in the metaphyseal area of long bones involving the growth plate, with majority of the cases occurring in the distal femur and proximal febia (Longhi et al, 2006;Cotterill et al, 2004). Around 25% of the osteosarcoma patients have already advanced to metastatic stage at diagnosis and lungs are the most common region where the tumor migrates (Wesolowski and Budd, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Although it can occur at any age, it is predominantly a disease that afflicts the young with a peak incidence in the second and third decades of life [9]. Numerous variables have been associated with an adverse prognosis in osteosarcoma including metastatic disease at presentation, nonosteoblastic histological subtype, tumor size, male gender, young age, tumor location, genetic variations, poor response to neoadjuvant chemotherapy, and inadequate surgical margins [4,7,10,12].…”
Section: Introductionmentioning
confidence: 99%