Statistics of ultrasonic scatterer size estimation with a reference phantom

In a companion paper [T. A. Bigelow and W. D. O'Brien Jr., J. Acoust. Soc. Am. 116, 578 (2004)], theory, supported by simulations, showed that accurate scatterer size estimates could be obtained using highly focused sources provided that the derived generalized attenuation-compensation function was used and the velocity potential field near the focus could be approximated as a three-dimensional Gaussian. Herein, the theory is further evaluated via experimental studies. A calibration technique is developed to find the necessary equivalent Gaussian dimensions for a focused source using reflections obtained from a rigid plane scanned through the focus. Then, the theoretical analysis of focused sources is validated experimentally using three spherically focused ultrasound transducers to estimate the radius of glass beads imbedded in tissue mimicking phantoms. Both the impact of focusing (f/1, f/2, and f/4) and the effect of scatterer type (comparing glass bead results to simulation results that used scatterers with Gaussian impedance distributions) were tested. The simulated differences agree with the measured differences to within 2.5% provided that the comparison is made between the same scatterer type and sources with the same equivalent Gaussian dimensions. The improvement provided by the generalized attenuation-compensation function is greatly influenced by the type of scatterer whose size is being estimated and decreases as the wavelength dependence of the Gaussian depth of focus is reduced.

Section: Discussionmentioning

confidence: 99%

Scatterer size estimation in pulse-echo ultrasound using focused sources: Calibration measurements and phantom experiments

Bigelow

O’Brien

2004

“…This fit was done over each transducer's available bandwidth. 17 Thus the effective scatter size estimate (d) is obtained by,…”

Section: Data Collection and Analysismentioning

confidence: 99%

Cross-imaging system comparison of backscatter coefficient estimates from a tissue-mimicking material

Nam

Rosado‐Mendez

Wirtzfeld

et al. 2012

A key step toward implementing quantitative ultrasound techniques in a clinical setting is demonstrating that parameters such as the ultrasonic backscatter coefficient (BSC) can be accurately estimated independent of the clinical imaging system used. In previous studies, agreement in BSC estimates for well characterized phantoms was demonstrated across different laboratory systems. The goal of this study was to compare the BSC estimates of a tissue mimicking sample measured using four clinical scanners, each providing RF echo data in the 1-15 MHz frequency range. The sample was previously described and characterized with single-element transducer systems. Using a reference phantom for analysis, excellent quantitative agreement was observed across the four array-based imaging systems for BSC estimates. Additionally, the estimates from data acquired with the clinical systems agreed with theoretical predictions and with estimates from laboratory measurements using single-element transducers.

“…Several transducer geometries have been studied in the past including unfocused 5 and focused 6,7 single-element transducers, as well as array systems. 8,9 Even for a fixed experimental system, several spectrum calibration methods have been proposed resulting in several methodologies for BSC estimation. Two of the most common ways of compensating for system-dependent effects are the substitution [10][11][12] and reference phantom [13][14][15] methods.…”

mentioning

confidence: 99%

On the estimation of backscatter coefficients using single-element focused transducers

Lavarello

Ghoshal

Oelze³

2011

The ultimate goal of quantitative ultrasound (QUS) imaging methods based on backscatter coefficient (BSC) estimates is to obtain system-independent structural information about samples. In the current study, three BSC estimation methods were compared and evaluated using the same backscattered pressure datasets in order to assess their consistency. BSC estimates were obtained from two phantoms with embedded glass spheres and compared to theoretical BSCs calculated using size distributions estimated using optical microscopy. Effective scatterer diameter and concentration estimates of the glass spheres were also obtained from the estimated BSCs. One estimation method needed to be compensated by more than an order of magnitude in amplitude in order to produce BSCs comparable to the other two methods. All calibration methods introduced different frequency-dependent effects, which could have noticeable effects on the bias of QUS estimates derived from experimental BSCs. Although in most cases the experimental QUS estimates obtained with all three methods were observed to differ by less than 10%, larger differences are expected depending on both the pressure focusing gain of the transducer (proportional to the ratio of the square of the aperture radius to the product of the wavelength and focal length) and ka range used in the estimation.