Statistically optimised sequestration of mefenamic acid from polluted water by acacia gum phthalate/pectin hydrogel: A novel multifunctional adsorbent material synthesised via microwave-assisted process

Pectin hydrogels for controlled drug release: Recent developments and future prospects

“…Sulfasalazine served as the prototype medication for incorporation into the tailored hydrogel formulations. Investigation into swelling and release behaviors demonstrated the hydrogels' capacity for targeted drug release under colonic pH conditions, with subsequent toxicological assessments affirming their safety in mouse models ( Abbasi et al, 2023 ).

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“…The investigation on drug release revealed a sustained liberation of 5-fluorouracil over a period exceeding 12 h, characterized by a gradual and consistent release profile ( Wang et al, 2023 ). Abbasi et al (2023) introduced an innovative hydrogel for precise drug delivery, utilizing a grafting approach that combined polyethylene glycol (PEG) and methacrylic acid (MAA) with pectin through free radical polymerization ( Fig. 3 ).…”

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Fig. 3 Schematic representation of hydrogel formation (reproduced with permission from Abbasi et al, 2023 ).

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“… Wu et al (2020) successfully designed a physically crosslinked pectin-based hydrogel characterized by remarkable stretchability and toughness, making it a promising candidate for biomedical applications. In addition, Abbasi et al (2023) introduced a novel multifunctional adsorbent material, namely acacia gum phthalate/pectin hydrogel, which was synthesized via a microwave-assisted process. This material was statistically optimized for the efficient sequestration of mefenamic acid from contaminated water.…”