In this work, a back-propagation artificial neural network model was optimally developed based on 25 experimental datasets for predicting the energy loss percentage of natural rubber foam. The foam specimens were prepared in a Banbury internal mixer at various conditions of mixing temperature (40-80°C), rotor speed (40-80 rpm), and mastication time (1-5 min). Stress-strain loops were analyzed by applying compressive force at aspeed test of 500 mm/min with the capacity of load cell 2.5 kN, the energy loss was further calculated. In model development, the experimental datasets were randomly divided into 70:15:15 for training, validation, and testing respectively. Levenberg-Marquardt algorithm was used as a training function was used because of its fast convergence. The prediction results revealed that the average prediction accuracy of the three models is higher than 90%. From a material design point of view, the developed model could be implemented to find the proper mixing conditions to obtain the material with the maximum energy dissipation.