Statistical Quality Control of Rabbit Brain Thromboplastin for Clinical Use in the Prothrombin Time Determination

Fisher, Lyman M.; Humphries, Betty Lou

doi:10.1093/ajcp/45.2.148

Cited by 4 publications

(4 citation statements)

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“…Shortly after the initiation of formal process analysis DTNTs were reduced significantly and remained within a narrow range, now showing a stable and statistically controlled pattern. Thus, process quality was significantly improved by our efforts'' (Bonetti et al, 46 p 315) 3 SPC application helped people identify areas for improvement 21 26 40 42 47 49 58 70 Several investigators identified process performance that was not satisfactory, and hence in need of improvement, using SPC. For instance, investigators applying SPC to the care of patients with asthma concluded that when the care process yields a range of breathing that ''is clinically problematic, the care process should be redesigned and monitored to ensure that the problem has been corrected'' (Boggs et al, 40 …”

mentioning

confidence: 99%

Application of statistical process control in healthcare improvement: systematic review

Thor

Lundberg

Ask

et al. 2007

Quality and Safety in Health Care

318

224

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Objective: To systematically review the literature regarding how statistical process control-with control charts as a core tool-has been applied to healthcare quality improvement, and to examine the benefits, limitations, barriers and facilitating factors related to such application. Methods: A standardised data abstraction form was used for extracting data relevant to the review questions, and the data were analysed thematically. Results: Statistical process control was applied in a wide range of settings and specialties, at diverse levels of organisation and directly by patients, using 97 different variables. The review revealed 12 categories of benefits, 6 categories of limitations, 10 categories of barriers, and 23 factors that facilitate its application and all are fully referenced in this report. Statistical process control helped different actors manage change and improve healthcare processes. It also enabled patients with, for example asthma or diabetes mellitus, to manage their own health, and thus has therapeutic qualities. Its power hinges on correct and smart application, which is not necessarily a trivial task. This review catalogues 11 approaches to such smart application, including risk adjustment and data stratification. Conclusion: Statistical process control is a versatile tool which can help diverse stakeholders to manage change in healthcare and improve patients' health.

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mentioning

confidence: 99%

Application of statistical process control in healthcare improvement: systematic review

Thor

Lundberg

Ask

et al. 2007

Quality and Safety in Health Care

318

224

View full text Add to dashboard Cite

show abstract

“…Automatic determination of the end-point of clotting-time has been reported to improve the precision of one-stage prothrombin time procedures (Fisher and Humphries 1966;Koepke 1970). This observation could not be confirmed in the present investigation.…”

Section: Discussionmentioning

confidence: 99%

“…The quality control of laboratory tests used to estimate coagulation activity has seriously been hampered by technical difficulties associated with the large scale preparation of suitable test materials giving comparable values with different methods and thromboplastins. Mainly due to this fact, only a few studies have been published on this subject, most of them dealing with various modification of the one-stage prothrombin time determination (Sub-Committe Report 1964; Miale and LaFond 1967;van Horn 1968;Koepke 1970 ;Zucker et al 1970;Miale and Kent 1973).…”

Section: Introductionmentioning

confidence: 99%

Regional Quality Control of Coagulation Assay Procedures (Normotest, Simplastin-A and Thrombotest)

Kahan¹

1974

Thromb Haemost

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SummaryThe report is based on the first 8 months’ operation of an extended regional quality control program involving 20 hospital laboratories in the Stockholm area. The test material was a commercially available lyophilized human reference plasma containing uniformly reduced levels of factors II, VII and X, and optimal concentrations of fibrinogen and factor V. Each participant received 2 batches of the test material with different activity at each 4-week period. Participants were requested to analyze the specimens, independently and in duplicates, along with ordinary patient samples three times weekly during each period. The levels of the factors in the batches were changed in each period. The total number of reported results was 3113. The statistical analysis of values included the calculation of means and variances within and between different thromboplastins (Normotest, Simplastin-A, Thrombotest), different techniques (venous and capillary blood, automatic and manual end-point determination), and laboratories classified according to the category and number of personnel and of performed coagulation tests. Systematic differences between thromboplastins, techniques and laboratories, even using the same type of thromboplastin, contributed a significantly greater amount than within-laboratory random variation to the total variation of determinations. The obtained results indicate the urgency of the quality control of coagulation activity tests.

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“…FPs are similar to control charts (CCs), which are widely used in manufacturing engineering in Statistical Process Control (SPC). SPC first appeared in medical literature in 1966 24 and is also termed Next Generation Quality (NGQ). 25,26 NGQ is continuous quality improvement using objective clinical data to provide feedback within a formal setting.…”

mentioning

confidence: 99%

Application of Next Generation Quality/Statistical Process Control and Expert-Led Case Review to Increase the Consistency of Diagnostic Rates in Precancerous Colorectal Polyps

Bonert¹,

Collins²,

Xenodemetropoulos³

et al. 2021

Quality Management in Health Care

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Statistical Quality Control of Rabbit Brain Thromboplastin for Clinical Use in the Prothrombin Time Determination

Cited by 4 publications

References 0 publications

Application of statistical process control in healthcare improvement: systematic review

Application of statistical process control in healthcare improvement: systematic review

Regional Quality Control of Coagulation Assay Procedures (Normotest, Simplastin-A and Thrombotest)

Application of Next Generation Quality/Statistical Process Control and Expert-Led Case Review to Increase the Consistency of Diagnostic Rates in Precancerous Colorectal Polyps

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