Statistical profiles of malignant melanoma and other skin cancers in Japan: 2007 update

Ishihara, Kazuyuki; Saida, Toshiaki; Otsuka, Fujio; Yamazaki, Naoya

doi:10.1007/s10147-007-0751-1

Cited by 184 publications

(151 citation statements)

References 9 publications

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“…Therefore expression of wild type allele type (Isoleucine) has been shown to be protective against tumor progression. Although previous study indicated that polymorphism at the GSTP1 locus would be an important factor in susceptibility to bladder and testicular cancer [4] Although the reason for the discrepancy between the result of our study and that of the studies in Caucasian population remains unknown, we could hypothesize that the genetic factors involved in melanomagenesis vary among races and also skin types [16,17]. Curtin et al also reported that genetic backgrounds which correlate with the mechanisms of melanomagenesis are different between ALM melanoma and the other types of MM such as LMM and SSM [18].…”

Section: Discussioncontrasting

confidence: 86%

GSTM1 Null Genotype is Associated with an Increased Risk of Cutaneous Malignant Melanoma in the Japanese Population

Chiyomaru¹

2013

J Med Diagn Meth

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Variations in the Glutathione S-transferase (GST) supergene family have been reported to influence cancer susceptibility in Caucasian. However the genetic backgrounds and skin types are quite different between Caucasian and non-Caucasian. We therefore investigated the distribution of GST gene polymorphism in a Japanese population to ascertain the role of this polymorphism in melanomagenesis. Forty-six patients with cutaneous malignant melanoma and 92 healthy individuals who visited Kobe University Hospital between April 2004 and November 2010 were enrolled in this study. Genotype of GST gene was determined by using polymerase chain reaction-restriction fragments length polymorphism analysis. The frequencies of GSTM1 null genotype were significantly different between malignant melanoma and controls (adjusted odds ratio=2.25, 95% confidence interval 1.06-4.77). The polymorphism of GSTM1 locus could be associated with cutaneous malignant melanoma risk among Japanese population.

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Section: Discussioncontrasting

confidence: 86%

GSTM1 Null Genotype is Associated with an Increased Risk of Cutaneous Malignant Melanoma in the Japanese Population

Chiyomaru¹

2013

J Med Diagn Meth

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“…Melanoma has initially been diagnosed in approximately 1500 patients per year and its rate is increasing. A study by the Prognosis and Statistical Investigation Committee (PSIC) of the Japanese Skin Cancer Society (JSCS) showed that the numbers of patients with malignant melanoma in 22 hospitals over several years were 1717 (1987 -1991), 1991 (1992 -1996), and 2468 (1997 -2001) 5 . Trends in anatomical site and Clark's subtype in Japan are shown in Tables 1 and 2 6 .…”

Section: Melanoma In Japanmentioning

confidence: 99%

Sentinel lymph node biopsy in Japan

2009

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Similar to western countries, intraoperative lymphatic mapping and selected lymphadenectomy (SNB) have been verified and are widely performed for staging of melanoma in Japan. Recent studies showed that approximately 90% (73/81) of university hospitals and several cancer hospitals routinely perform SNB, and half of melanoma patients receive this examination. SNB is performed according to a variation of the standard procedure described by Morton and Cochran. The most frequently used tracers are Tc 99m -tin colloid or Tc 99m -phytate for scintigraphy and patent blue violet or indigo carmine as a blue dye. Some institutions use indocyanine green, which is fluorescent and can be used to visualize sentinel lymph node(s) (SN) under an infrared camera. The recent detection rates of SN has increased to over 95% with the method using blue dye, lymphoscintigraphy, and a handheld gamma probe. In a multicenter study, the rates of metastasis in SN were as follows: pTis, 0% (0/36); pT1, 11.3% (6/56); pT2, 21.0% (13/63); pT3, 34.0% (35/103); and pT4, 62.4% (63/101). Metastasis rate was also significantly related with ulceration of the primary tumor. Here, we discuss data from Japanese patients and the present status of SNB in Japan.Introduction Lymph node metastasis is one of the most powerful predictors of recurrence and survival in patients with melanoma 1 . Therefore, elective lymph node dissection (ELND) has been widely used in the treatment of these patients. However, in several randomized controlled trials, overall survival benefits of ELND were not confirmed and ELND is becoming less common, especially in the USA 2 . In Japan, ELND had been accepted as the standard management in patients with primary tumors more than 3 mm in thickness. Intraoperative lymphatic mapping and selected lymphadenectomy (SNB) have made it possible to determine the lymphatic flow from a primary tumor and to identify its sentinel lymph node(s) (SN) in the regional basin 3,4 . This technique not only has lower morbidity than ELND but also permits more accurate and reliable staging. The new UICC/AJCC melanoma staging system has incorporated the pathological evaluation in SN into the new staging criteria for melanoma 1 . SLNB has been verified and is widely used as staging tool for melanoma in Japan. Here, we mainly discuss data from Japanese patients and the present status of sentinel node biopsy in Japan.

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“…The incidence rates range between 20 and 40 per 100,000 people in Australia and United States each year [1,2]. In contrast, the incidence in Asians is clearly lower, approximately one per 100,000 [3,4]. However, the most common clinical subtype of melanoma in Asians is acral lentiginous melanoma (ALM), which occurs at a rate of approximately 40%-65% of all cutaneous melanomas [4,5] compared with only 2%-3% in Caucasians [6].…”

Section: Introductionmentioning

confidence: 99%

Current Surgical Management of Acral Lentiginous Melanoma

Nakamura¹,

Teramoto²,

Sato³

et al. 2015

Melanoma - Current Clinical Management and Future Therapeutics

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Statistical profiles of malignant melanoma and other skin cancers in Japan: 2007 update

Abstract: In Japan, the number of patients with malignant skin tumors has increased year by year. The prognosis of patients with advanced malignant melanoma remains extremely poor, but that of patients in stage III has shown an improvement.

Cited by 184 publications

References 9 publications

GSTM1 Null Genotype is Associated with an Increased Risk of Cutaneous Malignant Melanoma in the Japanese Population

GSTM1 Null Genotype is Associated with an Increased Risk of Cutaneous Malignant Melanoma in the Japanese Population

Sentinel lymph node biopsy in Japan

Current Surgical Management of Acral Lentiginous Melanoma

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