Most of Italian companies are small or medium enterprises. Apart from few industrial areas, companies carry out their production in mixed areas in urban context. This opens several issues in terms of health protection of citizens, especially from exposure to noise. This work investigates Bolzano industrial area as a case study to discuss how the different policies might deal with health and noise issues. The site is chosen for its settlements originating long time ago, with its background mainly related to the history of the steelworks. Born as an exclusive industrial site, the actual situation is mix of industries, university and offices. Furthermore, Bolzano has a particularly low background noise, making the noise issue even more participated by citizens, as their annoyance threshold is very low. In this context, Bolzano acoustic zoning was attempted several times, but has never been approved due to the great challenge of combining economic and health impacts especially in the industrial area. Following the 2022 new acoustic zoning proposal, still under development, the paper describes the policies constraints with regards to properties values, mixed use of the industrial area, city development, current energy issues and obviously health protection that should be taken into account in zoning process.