Statistical parametric mapping analysis of the relationship between regional cerebral blood flow and symptom clusters of the depressive mood in patients with pre-dialytic chronic kidney disease

Kim, Seong-Jang; Song, Sang Heon; Kim, Ji Hoon; Kwak, Ihm Soo

doi:10.1007/s12149-007-0108-x

Cited by 15 publications

(12 citation statements)

References 25 publications

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“…Regarding our clinical sample, subjects with comorbid anxiety were included to improve generalizability of findings to MDD patients seeking care, but we did not have sufficient information to perform a stratified analysis of MRF cordance changes in individuals with or without anxiety; because our ROI has been implicated in anxiety conditions as well as in MDD by some studies (Blackhart et al, 2006; Kline and Allen, 2008; Kim et al, 2008; Gotlib, 1998. Schmidt, 1999) though not by all (e.g., Warwick et al, 2008), future investigations may usefully record the presence and severity of comorbid anxiety-spectrum symptoms and disorders to permit such analyses.…”

Section: Discussionmentioning

confidence: 99%

Midline and right frontal brain function as a physiologic biomarker of remission in major depression

Cook¹,

Hunter²,

Abrams³

et al. 2009

Psychiatry Research: Neuroimaging

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Prior investigations have reported that changes in the prefrontal electroencephalogram (EEG) precede symptom improvement from antidepressant medications, and could serve as a biomarker of treatment outcome in major depressive disorder (MDD). A new physiologically-defined region of interest, overlying the midline and right frontal (MRF) cortical area, was examined here for a relationship between early decreases in theta-band cordance and remission. Subjects were 72 adults with unipolar MDD who had completed placebo-controlled antidepressant treatment trials, with 37 randomized to medication and 35 to placebo. We assessed changes in cordance and absolute and relative power in the MRF region at 48 hours, 1 week, and 2 weeks after start of drug, as potential predictors of remission (final Ham-D 17 ≤5). Eleven of 37 medication subjects (30%) remitted vs 6 of 35 placebo subjects (17%). Change in MRF cordance one and two weeks after start of drug was significantly associated with remission in medication subjects (P=0.02 at 1 week), with Receiver Operating Characteristic (ROC) analysis yielding 0.76 area under the curve. Decreases in MRF cordance at 1 week predicted remission with medication with 69% overall accuracy (90% sensitivity; 60% specificity). MRF cordance changes were not associated with remission with placebo. Absolute and relative power did not differentiate groups. These results suggest that remission may be predictable from physiologic measurements after 1 week of treatment, and that this region merits further investigation in the neurobiology of treatment response.

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Section: Discussionmentioning

confidence: 99%

Midline and right frontal brain function as a physiologic biomarker of remission in major depression

Cook¹,

Hunter²,

Abrams³

et al. 2009

Psychiatry Research: Neuroimaging

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“…One study has documented the presence of intracranial arachnoid cysts in ADPKD (13), but more studies examined MRI findings in patients undergoing various renal replacement therapies (RRTs) and have reported the presence of cerebral atrophy and decreased cerebral density in both white and gray matter (9,(14)(15)(16)(17)(18)(19)(20)(21). Walters et al (18) showed that five HD patients had postdialysis increases in cerebral volume compared with five controls.…”

Section: Findings In Adult Structural Neuroimaging Studiesmentioning

confidence: 99%

“…Conversely, improvement in depressive symptoms has been associated with higher perfusion in the left middle temporal gyrus and higher rCBF in the right parahippocampal gyrus (10,14). To date, no such studies have been conducted with children and adolescents with CKD.…”

Section: Functional Brain Imaging Techniques Show Circulatory Patternmentioning

confidence: 99%

Systematic Review of Structural and Functional Neuroimaging Findings in Children and Adults with CKD

Moodalbail

Reiser

Detre³

et al. 2013

Clinical Journal of the American Society of Nephrology

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Summary CKD has been linked with cognitive deficits and affective disorders in multiple studies. Analysis of structural and functional neuroimaging in adults and children with kidney disease may provide additional important insights into the pathobiology of this relationship. This paper comprehensively reviews neuroimaging studies in both children and adults. Major databases (PsychLit, MEDLINE, WorldCat, ArticleFirst, PubMed, Ovid MEDLINE) were searched using consistent search terms, and studies published between 1975 and 2012 were included if their samples focused on CKD as the primary disease process. Exclusion criteria included case reports, chapters, and review articles. This systematic process yielded 43 studies for inclusion (30 in adults, 13 in children). Findings from this review identified several clear trends: (1) presence of cerebral atrophy and cerebral density changes in patients with CKD; (2) cerebral vascular disease, including deep white matter hyperintensities, white matter lesions, cerebral microbleeds, silent cerebral infarction, and cortical infarction, in patients with CKD; and (3) similarities in regional cerebral blood flow between patients with CKD and those with affective disorders. These findings document the importance of neuroimaging procedures in understanding the effect of CKD on brain structure, function, and associated behaviors. Results provide a developmental linkage between childhood and adulthood, with respect to the effect of CKD on brain functioning across the lifespan, with strong implications for a cerebrovascular mechanism contributing to this developmental linkage. Use of neuroimaging methods to corroborate manifest neuropsychological deficits or perhaps to indicate preventive actions may prove useful to individuals with CKD.

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“…In their previous study using F-18-fluorodeoxyglucose positron emission tomography, they found that several voxel clusters had significantly decreased cerebral glucose metabolism in patients with chronic kidney disease who had not started dialysis, including the prefrontal cortex, superior temporal gyrus and middle temporal gyrus [33]. Kim et al reported that depressive mood and anxiety factors were negatively correlated with regional cerebral blood flow in bilateral superior temporal gyrus, right middle temporal gyrus and left superior frontal gyrus [34]. Thus, all of them cannot reflect the baseline directly as resting-state studies can.…”

Section: Discussionmentioning

confidence: 98%

Regional Homogeneity Changes in Hemodialysis Patients with End Stage Renal Disease: In Vivo Resting-State Functional MRI Study

Qiu

et al. 2014

PLoS ONE

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ObjectiveTo prospectively investigate and detect early cerebral regional homogeneity (ReHo) changes in neurologically asymptomatic patients with end stage renal disease (ESRD) using in vivo resting-state functional MR imaging (Rs-fMRI).MethodsWe enrolled 20 patients (15 men, 5 women; meanage, 37.1 years; range, 19–49 years) with ESRD and 20 healthy controls (15 men, 5 women; mean age, 38.3 years; range, 28–49 years). The mean duration of hemodialysis for the patient group was 10.7±6.4 monthes. There was no significant sex or age difference between the ESRD and control groups. Rs-fMRI was performed using a gradient-echo echo-planar imaging sequence. ReHo was calculated using software (DPARSF). Voxel-based analysis of the ReHo maps between ESRD and control groups was performed with a two-samples t test. Statistical maps were set at P value less than 0.05 and were corrected for multiple comparisons. The Mini-Mental State Examination (MMSE) was administered to all participants at imaging.ResultsReHo values were increased in the bilateral superior temporal gyrus and left medial frontal gyrus in the ERSD group compared with controls, but a significantly decreased ReHo value was found in the right middle temporal gyrus. There was no significant correlation between ReHo values and the duration of hemodialysis in the ESRD group. Both the patients and control subjects had normal MMSE scores (≥28).ConclusionsOur finding revealed that abnormal brain activity was distributed mainly in the memory and cognition related cotices in patients with ESRD. The abnormal spontaneous neuronal activity in those areas provide information on the neural mechanisms underlying cognitive impairment in patients with ESRD, and demonstrate that Rs-fMRI with ReHo analysis is a useful non-invasive imaging tool for the detection of early cerebral ReHo changes in hemodialysis patients with ESRD.

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Statistical parametric mapping analysis of the relationship between regional cerebral blood flow and symptom clusters of the depressive mood in patients with pre-dialytic chronic kidney disease

Cited by 15 publications

References 25 publications

Midline and right frontal brain function as a physiologic biomarker of remission in major depression

Midline and right frontal brain function as a physiologic biomarker of remission in major depression

Systematic Review of Structural and Functional Neuroimaging Findings in Children and Adults with CKD

Regional Homogeneity Changes in Hemodialysis Patients with End Stage Renal Disease: In Vivo Resting-State Functional MRI Study

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