Statistical optimization of hydrazone-crosslinked hyaluronic acid hydrogels for protein delivery

Mozipo, Esther A.; Galindo, Alycia N.; Khachatourian, Jenna D.; Harris, Conor G.; Dorogin, Jonathan; Spaulding, Veronica R.; Ford, Madeleine R.; Singhal, Malvika; Fogg, Kaitlin C.; Hettiaratchi, Marian H.

doi:10.1039/d3tb01588b

Cited by 2 publications

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References 60 publications

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“…A hydrazone linkage in HA, also known as HA hydrazide, is a type of chemical modification used to add specific functionalities or create conjugates for different biomedical applications. Hydrazone linkages are created via the reaction between a hydrazide group (-NHNH 2 ) and an aldehyde or ketone group, resulting in a stable covalent bond (Figure 8) [75,76]. The original hydrazide modification used adipic acid dihydrazide (ADH) initially, followed by other mono-and polyhydrazides, to develop living HA derivatives.…”

Section: Hydrazone Linkagementioning

confidence: 99%

Exploring the Progress of Hyaluronic Acid Hydrogels: Synthesis, Characteristics, and Wide-Ranging Applications

Gholamali,

Vu,

et al. 2024

Materials

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This comprehensive review delves into the world of hyaluronic acid (HA) hydrogels, exploring their creation, characteristics, research methodologies, and uses. HA hydrogels stand out among natural polysaccharides due to their distinct features. Their exceptional biocompatibility makes them a top choice for diverse biomedical purposes, with a great ability to coexist harmoniously with living cells and tissues. Furthermore, their biodegradability permits their gradual breakdown by bodily enzymes, enabling the creation of temporary frameworks for tissue engineering endeavors. Additionally, since HA is a vital component of the extracellular matrix (ECM) in numerous tissues, HA hydrogels can replicate the ECM’s structure and functions. This mimicry is pivotal in tissue engineering applications by providing an ideal setting for cellular growth and maturation. Various cross-linking techniques like chemical, physical, enzymatic, and hybrid methods impact the mechanical strength, swelling capacity, and degradation speed of the hydrogels. Assessment tools such as rheological analysis, electron microscopy, spectroscopy, swelling tests, and degradation studies are employed to examine their attributes. HA-based hydrogels feature prominently in tissue engineering, drug distribution, wound recovery, ophthalmology, and cartilage mending. Crafting HA hydrogels enables the production of biomaterials with sought-after qualities, offering avenues for advancements in the realm of biomedicine.

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Section: Hydrazone Linkagementioning

confidence: 99%

Exploring the Progress of Hyaluronic Acid Hydrogels: Synthesis, Characteristics, and Wide-Ranging Applications

Gholamali,

Vu,

et al. 2024

Materials

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A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels

Ranamalla,

Tavakoli,

Porfire

et al. 2024

Carbohydrate Polymers

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Statistical optimization of hydrazone-crosslinked hyaluronic acid hydrogels for protein delivery

Abstract: Hydrazone-crosslinked hydrogels are attractive protein delivery vehicles for regenerative medicine. However, each regenerative medicine application requires unique hydrogel properties to achieve an ideal outcome. The properties of a hydrogel can...

Cited by 2 publications

References 60 publications

Exploring the Progress of Hyaluronic Acid Hydrogels: Synthesis, Characteristics, and Wide-Ranging Applications

Exploring the Progress of Hyaluronic Acid Hydrogels: Synthesis, Characteristics, and Wide-Ranging Applications

A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels

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