Statistical Optimization of Alkaline Protease Production by Newly Isolated Bacillus Strain using Industrial Skin Waste as a Novel Substrate

Abstract

pharmaceutical companies and detergent producing industries (Kumar et al., 2012). These catalysts can be roughly calculated for 60 to 65% of the world enzymes market which easily made them to be the most efficient and widely used in term of their industrial usages (Laxman et al., 2005). Proteases are enzymes which hydrolyses peptide bonds among amino acids groups of proteins. The hydrolytic enzymes are accounted for almost 75% of the global sales for industrial usages which are used in different areas along with proteolytic enzymes that are almost 60% in them (Ningthoujam et al., 2009;Chu, 2007).Alkaline proteases are among the most important groups of commercially used enzymes which are