Statistical optimization and valuable applications of bioactive compounds produced by marine Pseudoalteromonas piscicida

Guimarães, Cid

doi:10.7324/japs.2017.71012

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…(61) tested the antiviral activity of di-n-octyl phthalate isolated from a marine actinomycetes isolate ( S. parvus ) against hepatitis C virus (HCV). Compounds produced by Pseudoalteromonas piscida contained benzene 1-pentyloctyl, benzene 1-butylheptyl and di-n-octyl phthalate, and these compounds were found to be active against HCV (62). Yin et al .…”

Section: Discussionmentioning

confidence: 99%

Antiviral viral compound fromStreptomyces ghanaensislike strain against white spot syndrome virus (WSSV) of shrimp

Rajkumar¹,

Manimaran

Taju³

et al. 2018

Preprint

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35Actinomycetes isolates collected from different environments were screened for 36 antiviral activity against WSSV. One isolate designated as CAHSH-2 showed antiviral 37 activity against WSSV at the concentration of 0.2 mg per shrimp. The laboratory trial of 38 determining antiviral activity of ethyl acetate extract (EtOAcE) of CAHSH-2 against WSSV 39 was carried out 21 times since 2014. CAHSH-2 isolate which showed antiviral activity was 40 characterized and identified as Streptomyces ghanaensis like strain. Among the five fractions 41 obtained from EtOAcE of potential actinomycetes isolate, F1 was found to have strong 42 antiviral activity. The F1A and F1B sub-fractions from F1 fraction were subjected to GC-MS, 43 FTIR, 1 H and 13 C NMR analyses and, the compounds identified were di-n-octyl phthalate and 44 bis (2-methylheptyl) phthalate, respectively. Among these compounds, di-n-octyl phthalate 45 showed strong antiviral activity against WSSV. Molecular docking studies revealed that di-n-46 octyl phthalate was found to have high binding affinity with VP26 and VP28 proteins of 47 WSSV, whereas the bis (2-methylheptyl) phthalate showed low binding affinity with VP26 48 and VP28. The antiviral activity of EtOAcE of actinomycetes against WSSV was confirmed 49 by PCR, RT-PCR, Western blot and ELISA. The EA extract of active isolate was found to be 50 non-toxic to Artemia, post-larvae and adult Litopenaeus vannamei. 51 Importance 52 53White spot syndrome virus (WSSV) is an important shrimp viral pathogen and 54 responsible for huge economic loss to shrimp culture industry worldwide including India. The 55 global loss due to WSSV has been estimated about USD 10 billion and the loss continues at 56 the same extent even now. Various strategies have been followed to prevent or control 57 diseases of aquatic animals. In spite of various preventive and control strategies, WSSV has 58 been still persisting for more than two decades. No control strategies have so far been evolved 59 to put a break to WSSV. In this situation, an attempt was made in the present work to screen 60 some actinomycetes isolates for antiviral activity against WSSV. Among these isolates, one 61 isolate identified as Streptomyces ghanaensis like isolate CAHSH-2 showed activity against 62 WSSV. This article gives the information about the antiviral compound against WSSV and 63 the mechanism of viral inhibition. 64 65 66

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Section: Discussionmentioning

confidence: 99%

Antiviral viral compound fromStreptomyces ghanaensislike strain against white spot syndrome virus (WSSV) of shrimp

Rajkumar¹,

Manimaran

Taju³

et al. 2018

Preprint

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“…have been reported to be able to produce several bioactive compounds, including antitumour (Ivanova et al, 2004), antibacterial (Isnansetyo & Kamei, 2003;Long et al, 2003), and antimalarial drugs (Kim et al, 1999). Pfiesteria piscicida from Suez Bay has anticancer and antiviral activities as it contains benzene 1-butylheptyl; benzene 1-pentyloctyl; and di-n-octyl phthalate (Hassan et al, 2017). Violacein and indolmycin from P. luteoviolaceae S4054 exert antibacterial effect against V. anguillarum and S. aureus (Thøgersen et al, 2016).…”

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confidence: 99%

Anti‐ Vibrio activity of Pseudoalteromonas xiamenensis STKMTI.2, a new potential vibriosis biocontrol bacterium in marine aquaculture

Handayani

Isnansetyo

Istiqomah

et al. 2021

Aquaculture Research

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Vibriosis is a prevalent disease in almost all mariculture species worldwide. The pathogens causing this disease can survive freely in water regardless of the host and can very easily infect marine organisms in warm water (Klesius & Pridgeon, 2011). They cause the death of shrimp and marine fish (Istiqomah et al., 2020), which in turn leads to severe economic losses and becomes a major public health problem. These causative bacteria are classified as Gram-negative and opportunistic pathogens that infect the marine organisms when the host is under stress. Clinical signs of infected fish include anorexia, eyes opacity, pigmentation of the fish skin, skin ulcers, lesions in the muscle, exophthalmia, ulcers in the eye, fin rot, and swollen intestines (Mohamad et al., 2019;Zhang et al., 2014).Vibriosis is controlled by administering quinolone, tetracycline and erythromycin. However, the application of antibiotics strengthens the antibiotic-resistant Vibrio. Vibrio spp. have become resistant to antibiotics commonly used for treatment (Isnansetyo et al., 2009). Vibrio campbellii is resistant to oxytetracycline, ampicillin and carbenicillin (Nakayama et al., 2006). It has also been reported that some strains of V. harveyi have become resistant to more than three types of antibi-

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Bioactivity of Metabolites from Actinomycetes Isolates from Red Sea, Egypt

Osman

El-Nasr

Hussein

et al. 2022

Microbiol. Biotechnol. Lett.

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Actinomycetes isolated from marine habitats represent a promising source of bioactive substances. Here, we report on the isolation, identification, productivity enhancement and application of the bioactive compounds of Streptomyces qinglanensis H4. Eighteen marine actinomycetes were isolated and tested for resistance to seven bacterial diseases. Using 16S rRNA sequencing analysis (GenBank accession number MW563772), the most powerful isolate was identified as S. qinglanensis. Although the strain produced active compound(s) against a number of Gram-negative and Gram-positive bacteria, it failed to inhibit pathogenic fungi. The obtained inhibition zones were 22.0 ± 1.5, 20.0 ± 1, 16.0 ± 1, 12.0 ± 1, 22.0 ± 1 and 24.0 ± 1 mm against Bacillus subtilis ATCC 6633, Escherichia coli ATCC 19404, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 9027, Candida albicans ATCC 10231 and Staphylococcus aureus ATCC6538, respectively. To maximize bioactive compound synthesis, the Plackett-Burman design was used. The productivity increased up to 0.93-fold, when S. qinglanensis was grown in optimized medium composed of: (g/l) starch 30; KNO 3 0.5; K 2 HPO 4 0.25; MgSO 4 0.25; FeSO 4 •7H 2 O, 0.01; sea water concentration (%) 100; pH 8.0, and an incubation period of 9 days. Moreover, the anticancer activity of S. qinglanensis was tested against two different cell lines: HepG2 and CACO. The inhibition activities were 42.96 and 57.14%, respectively. Our findings suggest that the marine S. qinglanensis strain, which grows well on tailored medium, might be a source of bioactive substances for healthcare companies.

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Statistical optimization and valuable applications of bioactive compounds produced by marine Pseudoalteromonas piscicida

Cited by 3 publications

References 15 publications

Antiviral viral compound fromStreptomyces ghanaensislike strain against white spot syndrome virus (WSSV) of shrimp

Antiviral viral compound fromStreptomyces ghanaensislike strain against white spot syndrome virus (WSSV) of shrimp

Anti‐ Vibrio activity of Pseudoalteromonas xiamenensis STKMTI.2, a new potential vibriosis biocontrol bacterium in marine aquaculture

Bioactivity of Metabolites from Actinomycetes Isolates from Red Sea, Egypt

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