Statistical motion modelling for robust evaluation of clinically delivered accumulated dose distributions after curative radiotherapy of locally advanced prostate cancer

High accumulated doses to the inferior rectum are associated with late gastro-intestinal toxicity in a case-control study of prostate cancer patients treated with radiotherapy

“…Rectal dose surface maps (DSMs) have been suggested as a solution to account for spatial patterns in associations between dose distributions and GI toxicity, potentially improving doseresponse relationships [11][12][13][14][15]. Statistical simulations of motion-inclusive accumulated doses have showed potentially stronger associations to morbidity risk than the planned doses [16][17][18]. Combining this with data from on-board 3D imaging (e.g.…”

Plan Selection in Proton Therapy of Locally Advanced Prostate Cancer with Simultaneous Treatment of Multiple Targets

“…In our training material, such large motion was rare (2.5%) and nonexistent among the testing patients Pat.20 Pat. 19 Pat Fig. 1, Fig.…”

“…Further details on the patient material and the IMRT treatment procedure for these patients can be found elsewhere. 19,20 The population-model of day-to-day motion for plan library construction motion model was derived describing the movement of the p-CTV in relation to ln-CTV, substituted by the intraprostatic GMs and pelvic BA, respectively. The global translation in the lateral, longitudinal, and vertical directions to align each rCT i (i Z 1.N) to the pCT for every patient, k (k Z 1.18) was described by the vector, v i;k GM for GM-and v i;k BA for BA-based registrations.…”

Ten-Year Results From a Phase II Study on Image Guided, Intensity Modulated Radiation Therapy With Simultaneous Integrated Boost in High-Risk Prostate Cancer

“…The treatment procedure has been presented in detail elsewhere, 25 but will be briefly described. Three clinical target volumes (CTV) were defined receiving different dose levels, with the higher dose levels administered as SIB.…”