Statistical Models of Parkinson’s Disease Progression: Predictive Validity in a 3-Year Follow-up

Mendes, Alexandre; Gonçalves, Alexandra; Vila‐Chã, Nuno; Calejo, Margarida; Moreira, Inês; Fernandes, Joana; Damásio, Joana; Teixeira‐Pinto, Armando; Krack, Paul; Lima, Alexandre Bastos; Cavaco, Sara

doi:10.3233/jpd-160877

Cited by 5 publications

(6 citation statements)

References 93 publications

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“…Lately, many long-lasting observations of patients with PD have been published (Hely et al, 1995;Reinoso et al, 2014;Ding et al, 2016;Kojovic et al, 2015;Di Battista et al, 2016;Mendes et al, 2016;Erro et al, 2016;Pedersen et al, 2017). Our present study demonstrated a favorable influence of regularly repeated non-invasive brain (N = 14).…”

Section: Discussionsupporting

confidence: 66%

“…variation. The yearly increment ranged between 1.2% and 3.8% depending on the applied scores (Mendes et al, 2016). They confirmed in their study that the different progression rates belonged to different Parkinsonian symptoms.…”

Section: ≤65mentioning

confidence: 65%

“…However, there is no pure drug-free period in patients who are regularly treated with levodopa. The progression continues in both phases of the on-phase and the off-phase (Ding et al, 2016;Mendes et al, 2016). In our study the patients were tested in the drug active phase of the day.…”

Section: Tablementioning

confidence: 99%

“…The appearance of dementia and postural instability predicts the worsening of PD (Hely et al, 1995;Evans et al, 2011). The progression rate was different in the follow-up studies (Reinoso et al, 2014;Hely et al, 1995;Di Battista et al, 2016;Liu et al, 2015aLiu et al, , 2015bErro et al, 2016;Pedersen et al, 2017;Mendes et al, 2016). They agreed that the appearance of non-motor symptoms significantly depressed the quality of life of patients with PD, even if their motor ability was the same (Erro et al, 2016).…”

Section: Introductionmentioning

confidence: 98%

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Long Term Follow-Up Study with non-invasive brain stimulation (NBS) (rTMS and tDCS) in Parkinson’s disease (PD). Strong Age Dependency in the Effect of NBS

Málly¹,

Geisz²,

Stone

et al. 2019

Brain Stimulation

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Background: Transcranial magnetic stimulation (rTMS) may influence the progression of PD compared with levodopa. The long term mind modification effect of repeated rTMS and tDCS is not known, nor are the predictors for the effect of NBS. Objective/hypothesis: We hypothesized that the regularly repeated rTMS would decrease the development of PD. Later, the treatment protocol was completed with transcranial direct current stimulation (tDCS), supposing that there is an add-on effect. NBS may differently influence motor and mental aspects of the disease. Methods: Thirty patients with PD were followed for 3.5 years in an open study. They were stimulated with 1 Hz rTMS every half year for 1.5 years. After that the tDCS was add to the stimulation over both sides of the cerebellum for the next 2 years. UPDRS, Trail Making Test and dual tests were used. The linear regression lines of score systems and percentage of yearly increment were counted, analyzed by ANOVA. Results: The yearly progression rate for UPDRS total was 2% for 3.5 years, 0.6% ≤65 years, 3.6% > 65 years. The increment was around zero during the rTMS + tDCS stimulations in patients ≤65 years. The slope of the equation showed the same tendency. The individual sensitivity to the NBS was high. tTMS and tDCS > 65 yrs improved pathological executive function (p < 0.0001). Conclusion: The motor ability in PD was maintained at the same level in patients ≤65 years with NBS for the 3.5 years in contrast to patients > 65 years. The cognitive function of patients > 65 yrs was favorable influenced by rTMS and tDCS. Age is the main predictor of the effect of NBS. rTMS and tDCS can slow the progression of PD without any side effects but in an age-dependent way.

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Section: Discussionsupporting

confidence: 66%

Section: ≤65mentioning

confidence: 65%

Section: Tablementioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Long Term Follow-Up Study with non-invasive brain stimulation (NBS) (rTMS and tDCS) in Parkinson’s disease (PD). Strong Age Dependency in the Effect of NBS

Málly¹,

Geisz²,

Stone

et al. 2019

Brain Stimulation

View full text Add to dashboard Cite

show abstract

“…S&E referred to off and on state conditions. Based on UPDRS‐III off and on, an axial index (sum of items 18, 27, 28, 29 and 30) and a non‐axial index [sum of items 20 (except face, lips and chin tremor), 21, 22 (except neck rigidity), 23, 24, 25 and 26] were calculated (Bejjani et al, ; Mendes et al, ).…”

Section: Methodsmentioning

confidence: 99%

Unveiling the relationship between central parkinsonian pain and motor symptoms in Parkinson's disease

Vila‐Chã

Cavaco

Mendes

et al. 2019

European Journal of Pain

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Background Pain in Parkinson's disease (PD) is a common and heterogeneous non‐motor symptom. Although the characteristics and predictors of pain in general and of central pain in particular are still largely unknown. Methods A semi‐structured interview, the Brief Pain Inventory and the Pain Disability Index were used to identify and characterize pain in a consecutive series of 292 PD patients. Unified PD Rating Scale‐III, Hoehn & Yahr, Schwab and England Independence Scale and Freezing of Gait Questionnaire were applied to assess motor symptoms and functional independence in off and on conditions. Hospital Anxiety and Depression Scale and Questionnaire of Impulsive‐Compulsive Control Disorders were used to screen for anxiety, depression and impulse control disorders. Results Two hundred and twelve patients (73%) reported pain, which was classified as: musculoskeletal (63%), dystonia‐related (27%), central parkinsonian (22%) and/or radicular or neuropathic (9%). Patients with pain had more comorbidities and more severe motor symptoms. Patients with central parkinsonian pain were significantly younger, had earlier disease onset, fewer comorbidities, greater non‐axial motor symptom severity in on, more pain‐related disability and more relief of pain with antiparkinsonian medication than patients with non‐central parkinsonian pain. Conclusions PD patients with central parkinsonian pain have some distinctive demographic and clinical features, including lower levodopa responsiveness of motor appendicular/limb symptoms to levodopa, associated with greater responsiveness of pain symptoms to these same medications. These findings suggest the need for a more integrated approach to motor and non‐motor symptoms in these patients' clinical care. Significance In a consecutive series of 292 patients with PD, almost three quarters of patients with PD reported pain. The study results revealed that pain was related to more severe motor symptoms, anxiety symptoms and comorbidities. Among patients with pain, those with central parkinsonian subtype had distinct demographic and clinical features, including lower levodopa responsiveness for non‐axial motor symptoms and greater responsiveness of pain to antiparkinsonian treatment.

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Parkinson’s Tremor Data Analysis Device

Alanis

Cantú

León

et al. 2018

Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering

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Statistical Models of Parkinson’s Disease Progression: Predictive Validity in a 3-Year Follow-up

Abstract: A cross-sectional assessment of a PD population allowed the development of models of disease progression, whose predictive value was validated on a three-year longitudinal study.

Cited by 5 publications

References 93 publications

Long Term Follow-Up Study with non-invasive brain stimulation (NBS) (rTMS and tDCS) in Parkinson’s disease (PD). Strong Age Dependency in the Effect of NBS

Long Term Follow-Up Study with non-invasive brain stimulation (NBS) (rTMS and tDCS) in Parkinson’s disease (PD). Strong Age Dependency in the Effect of NBS

Unveiling the relationship between central parkinsonian pain and motor symptoms in Parkinson's disease

Parkinson’s Tremor Data Analysis Device

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