Statistical methods to detect mother–father genetic interaction effects on risk of infertility: A genome‐wide approach
Siri N. Skodvin,
Håkon K. Gjessing,
Astanand Jugessur
et al.
Abstract:Infertility is a heterogeneous phenotype, and for many couples, the causes of fertility problems remain unknown. One understudied hypothesis is that allelic interactions between the genotypes of the two parents may influence the risk of infertility. Our aim was, therefore, to investigate how allelic interactions can be modeled using parental genotype data linked to 15,789 pregnancies selected from the Norwegian Mother, Father, and Child Cohort Study. The newborns in 1304 of these pregnancies were conceived usi… Show more
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