Statistical methods for discrimination of STR genotypes using high resolution melt curve data
Darianne C. Cloudy,
Edward L. Boone,
Kristi Kuehnert
et al.
Abstract:Despite the improvements in forensic DNA quantification methods that allow for the early detection of low template/challenged DNA samples, complicating stochastic effects are not revealed until the final stage of the DNA analysis workflow. An assay that would provide genotyping information at the earlier stage of quantification would allow examiners to make critical adjustments prior to STR amplification allowing for potentially exclusionary information to be immediately reported. Specifically, qPCR instrument… Show more
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