Turbulent dynamical systems characterized by both a highdimensional phase space and a large number of instabilities are ubiquitous among complex systems in science and engineering, including climate, material, and neural science. Control of these complex systems is a grand challenge, for example, in mitigating the effects of climate change or safe design of technology with fully developed shear turbulence. Control of flows in the transition to turbulence, where there is a small dimension of instabilities about a basic mean state, is an important and successful discipline. In complex turbulent dynamical systems, it is impossible to track and control the large dimension of instabilities, which strongly interact and exchange energy, and new control strategies are needed. The goal of this paper is to propose an effective statistical control strategy for complex turbulent dynamical systems based on a recent statistical energy principle and statistical linear response theory. We illustrate the potential practical efficiency and verify this effective statistical control strategy on the 40D Lorenz 1996 model in forcing regimes with various types of fully turbulent dynamics with nearly one-half of the phase space unstable.statistical energy principle | response theory | statistical control T urbulent dynamical systems characterized by both a highdimensional phase space and a large number of instabilities are ubiquitous among complex systems in science and engineering (1-4), including climate, material, and neural science. Control of these complex systems is a grand challenge, for example, in mitigating the effects of climate change (5, 6) or safe design of technology with fully developed shear turbulence. Control of flows in the transition to turbulence, where there is a small dimension of instabilities about a basic mean state, is an important and successful discipline (7,8). In complex turbulent dynamical systems, it is impossible to track and control the large dimension of instabilities, which strongly interact and exchange energy (9), and new control strategies are needed.The goal here is to propose an effective statistical control strategy for complex turbulent dynamical systems based on a recent statistical energy principle (10, 11) and statistical linear response theory (12-14). We illustrate the potential practical efficiency and verify this effective statistical control strategy on the 40D Lorenz 1996 (L-96) model in forcing regimes with various types of fully turbulent dynamics with nearly one-half of the phase space unstable.i) The statistical control theory proposed here has the goal and theoretical steps in its design. A) Goal and statistical energy. The statistical energy, E , is the sum of the energy of the statistical mean and the trace of the statistical covariance (10, 11). A turbulent dynamical system is subjected to poorly known external forcing, and the goal of the statistical control strategy is to find an effective deterministic feedback control to drive the statistical energy measured at some time...