Statistical Correlation and Heparin Sensitivity of Activated Partial Thromboplastin Time, Whole Blood Coagulation Time, and an Automated Coagulation Time

Randomized, Controlled Trial of Individualized Heparin and Protamine Management in Infants Undergoing Cardiac Surgery With Cardiopulmonary Bypass

“…ACT measurements are being affected by many variables other than heparin such as hemodilution and hypothermia, as well as decreased platelet function. It is an inadequate monitor of anticoagulation (17,24). The prolongation of the ACT during bypass may lead to misinterpretation that adequate anticoagulation is present even when heparin levels may be inadequate.…”

“…Current anticoagulation practices in children have been extrapolated from adult protocols and are generally based on an empirical weight-based heparin and protamine dosing regimen using an automated whole blood activated clotting time (ACT) device to monitor anticoagulation. There has been very little validation of any of these protocols in young children (13)(14)(15)(16)(17)(18)(19).…”

Antithrombotics

“…This is a whole blood technique, reflecting the effects of all blood elements that play a role in thrombosis (SCHRIEVER et al 1973). This is a whole blood technique, reflecting the effects of all blood elements that play a role in thrombosis (SCHRIEVER et al 1973).…”

Percutaneous transluminal coronary angioplasty: Comparison of arterial vs. venous activated clotting time

“…The disadvantages of whole blood clotting time include a lack of precision and the prolonged time it takes to get results [4]. Activated partial thromboplastin time is also time-consuming and is only linear over a low heparin dose range [5,6]. ACT, on the other hand, is rapid and can be done within minutes at bedside.…”