Statistical classification of treatment responses in mouse clinical trials for stratified medicine in oncology drug discovery
Hélène Savel,
Florence Meyer-Losic,
Cécile Proust-Lima
et al.
Abstract:Translational oncology research strives to explore a new aspect: identifying subgroups that exhibit treatment response even during pre-clinical phases. In this study, we focus on PDX models and their implementation in mouse clinical trials (MCT). Our primary objective was to identify subgroups with different treatment responses using Latent Class Mixed Model (LCMM).We used a public dataset and focused on one treatment, encorafenib, and two indications, melanoma and colorectal cancer, for which efficacy depends… Show more
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