Statistical calculation of beta radiotherapy dose using I-131: analysis and simulation method.

Abstract

Radioiodine-131 (I-131) treats hyperthyroidism and differentiated thyroid carcinoma. In I-131, beta radiation (β−) is utilized for treatment and gamma radiation (γ) is used for diagnostic. This research sought to determine if a patient would be treated by establishing an equation for beta-thyroid cell interaction. The prospective study included 35 thyroid cancer patients receiving I-131 treatment. Beta and gamma readings were taken at different distances and sent to the statistical shop to find the coefficients of change on which the beta reaction depends and the equation that depends on it to find the beta range involved in healing. The strongest equation was R square (98.1%). To measure beta at 1 m, use the equation with a 99% association between variables and independent variables, and improve with ANOVA with a p-value of 0.00 0.05. The equation is: β_1m= -123.893+(0.947*δ) +(0.123*ε) -(0.002*π) -(2.11*Log Gamma). The discrepancy between true beta readings (mean = 1040) and the equation (mean = 1087, p-value = 0.411) is more than 0.05. That indicates the values are same. The equation that measures beta during iodine therapy has been achieved, which is the first step to improved thyroid cancer treatment.