Abstract:Background: Cluster randomized trials, which randomize groups of individuals to an intervention, are common in health services research when one wants to evaluate improvement in a subject's outcome by intervening at an organizational level. For many such trials sample size calculation is performed under the assumption of equal cluster size. Many trials that set out to recruit equal clusters end up with unequal clusters for various reasons. This leads to a misalignment between the method used for sample size ca… Show more
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