Statistical analysis on bio-efficacy of different solvent fraction of Andrographis paniculata against some bacteria

Abstract

Andrographis paniculata leaves on bacterial that cause diseases. And it was aimed to compare the effect of Andrographis paniculata on some selected bacteria with the normal antibiotics. The bacterial isolates used in the study were Staphylococcuc aurcus, Streptococcus pyogens, Proteus vulgaris and Escherichia coli. The data was collected by experimental method from laboratory as source of primary data. Randomized complete block design with two-way analysis of variance were used to analyze the data in order to determine the significant difference in efficacy of fractions solvent extract of Andrographis paniculata leaves on bacteria. The normal antibiotics used are: Streptomycin, Gentamycin, Amoxillin, Chloramphenicol, Contrimoxazole, ofloxaacin, Erthrommycin, ERX, PT and Ceftriaxone. MINITAB 16 statistical software were used for computation analysis of the data collected. The result of the analysis reveal that there is significant difference in the efficacy of different antibiotics on bacteria that cause diseases. Although it was observed that the level of inhibition of each antibiotics were not the same but they all possess antibicteria properties that could be used to treat some bacteria diseases. Therefore, it was concluded that Andrographis paniculata is highly potent in the treatment of some selected bacterial diseases. I hereby recommended that, the effective drugs could be produced from Andrographis paniculata leaves used in traditional medicine, thereby enhance self-reliance, more active drugs can be produced to solve the present-day problems of drug resistance in the health management.

Genomic Investigation on the Antimicrobial Activities and Toxicological Studies of Andrographis Paniculata (Vinegar) Leaf and Stem on Ed Human Pathogens

“…Among the extracts tested, the ethyl acetate extract displayed the highest zone of inhibition value (18.5 mm) against Staphylococcus aureus, indicating its potent antibacterial potential. The results of this investigation agrees with the findings of Emiola et al, (2021) where they investigated the bio-efficacy of different solvent fractions of Andrographis paniculata against some bacteria. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests quantitatively assessed the antibacterial activity, and the ethyl acetate and chloroform extracts exhibited MIC values ranging from 150 g/ml to 250 g/ml against Staphylococcus aureus and Pseudomonas aeruginosa.…”