The purpose of this paper is to conduct a seakeeping analysis of planing craft under regular wave with large wave height. To obtain a reliable numerical method to simulate the sailing of planing craft in waves, Reynolds-averaged Navier–Stokes (RANS) solver and overset method are adopted. The motion response and resistance of the planing craft USV01 in regular wave were numerical predicted and compared with the corresponding seakeeping experimental tests. The results show that the numerical method has high accuracy. For further study, a new planing craft whose name is improved vessel is selected for simulation, the low steaming of the USV01 and improved vessel in regular wave with large wave height was simulated, and the seakeeping of the two vessels was studied. The analysis about the influence of wave length on the motion response and navigation configurations of the improved vessel under regular wave was carried out. Meanwhile, the influence of speed on different navigation configurations of the improved vessel was also analyzed. The improved vessel can provide better seakeeping, and a reduction in the speed of the vessel will benefit its seakeeping, irrespective of its navigation configuration.