Statistical Analysis of Method Comparison Data: Testing Normality

Cembrowski, George S.; Westgard, James O.; Conover, W. J.; Toren, E. Clifford

doi:10.1093/ajcp/72.1.21

Cited by 22 publications

(13 citation statements)

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“…Measurements for the giantin KD do not follow a normal distribution as detected via the Lilliefors test at p ≤ 0.05 [60]; hence, hypothesis testing for different medians was performed via the non-parametric Wilcoxon rank sum test [61] for control versus giantin KD for the three parameters: cisternal length, intercisternal distance, and number of intercisternal connections. Data are expressed as mean ± SD.…”

Section: Discussionmentioning

confidence: 99%

Post-ER Stress Biogenesis of Golgi Is Governed by Giantin

Frisbie

Lushnikov

Krasnoslobodtsev

et al. 2019

Cells

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Background: The Golgi apparatus undergoes disorganization in response to stress, but it is able to restore compact and perinuclear structure under recovery. This self-organization mechanism is significant for cellular homeostasis, but remains mostly elusive, as does the role of giantin, the largest Golgi matrix dimeric protein. Methods: In HeLa and different prostate cancer cells, we used the model of cellular stress induced by Brefeldin A (BFA). The conformational structure of giantin was assessed by proximity ligation assay and atomic force microscopy. The post-BFA distribution of Golgi resident enzymes was examined by 3D SIM high-resolution microscopy. Results: We detected that giantin is rather flexible than an extended coiled-coil dimer and BFA-induced Golgi disassembly was associated with giantin monomerization. A fusion of the nascent Golgi membranes after BFA washout is forced by giantin re-dimerization via disulfide bond in its luminal domain and assisted by Rab6a GTPase. GM130-GRASP65-dependent enzymes are able to reach the nascent Golgi membranes, while giantin-sensitive enzymes appeared at the Golgi after its complete recovery via direct interaction of their cytoplasmic tail with N-terminus of giantin. Conclusion: Post-stress recovery of Golgi is conducted by giantin dimer and Golgi proteins refill membranes according to their docking affiliation rather than their intra-Golgi location.

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Section: Discussionmentioning

confidence: 99%

Post-ER Stress Biogenesis of Golgi Is Governed by Giantin

Frisbie

Lushnikov

Krasnoslobodtsev

et al. 2019

Cells

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“…The TTV value can be used to determine and track stress-trends in a feed-forward manner through online monitoring of variations in the observed signals as the absolute value indicates the significance of the change observed. TTV takes values between -1 to +1 which corresponds to 100% certainty of decreasing and increasing trends in the tracked feature 48 . The mathematical description of TTV calculation in the form of pseudocode algorithm is presented in Table 6.…”

Section: Stress-trend Analysismentioning

confidence: 99%

Assessment of Driver Stress from Physiological Signals collected under Real-Time Semi-Urban Driving Scenarios

Singh¹,

Conjeti²,

Banerjee³

2014

IJCIS

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Designing a wearable driver assist system requires extraction of relevant features from physiological signals like galvanic skin response and photoplethysmogram collected from automotive drivers during real-time driving. In the discussed case, four stress-classes were identified using cascade forward neural network (CASFNN) which performed consistently with minimal intra-and inter-subject variability. Task-induced stress-trends were tracked using -based regression model with CASFNN configuration. The proposed framework will enable proactive initiation of rescue and relaxation procedures during accidents and emergencies.

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“…Data were tested for normal distribution with the Lillifors test 20 . normally distributed data are presented as mean (SD), and skewed data as both median (interquartile range) and mean (SD).…”

Section: Discussionmentioning

confidence: 99%

Comparison between Conventional and Protective One-Lung Ventilation for Ventilator-Assisted Thoracic Surgery

Ahn

Kim

Yang

et al. 2012

Anaesth Intensive Care

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Recent papers suggest protective ventilation (PV) as a primary ventilation strategy during one-lung ventilation (OLV) to reduce postoperative pulmonary morbidity. However, data regarding the advantage of the PV strategy in patients with normal preoperative pulmonary function are inconsistent, especially in the case of minimally invasive thoracic surgery. Therefore we compared conventional OLV (V T 10 ml/kg, FiO 2 1.0, zero PEEP) to protective OLV (V T 6 ml/kg, FiO 2 0.5, PEEP 5 cmH 2 O) in patients with normal preoperative pulmonary function tests undergoing video-assisted thoracic surgery. Oxygenation, respiratory mechanics, plasma interleukin-6 and malondialdehyde levels were measured at baseline, 15 and 60 minutes after OLV and 15 minutes after restoration of two-lung ventilation. P a O 2 and P a O 2 /FiO 2 were higher in conventional OLV than in protective OLV (P <0.001). Interleukin-6 and malondialdehyde increased over time in both groups (P <0.05); however, the magnitudes of increase were not different between the groups. Postoperatively there were no differences in the number of patients with P a O 2 /FiO 2 <300 mmHg or abnormalities on chest radiography. Protective ventilation did not provide advantages over conventional ventilation for video-assisted thoracic surgery in this group of patients with normal lung function.

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Statistical Analysis of Method Comparison Data: Testing Normality

Cited by 22 publications

References 0 publications

Post-ER Stress Biogenesis of Golgi Is Governed by Giantin

Post-ER Stress Biogenesis of Golgi Is Governed by Giantin

Assessment of Driver Stress from Physiological Signals collected under Real-Time Semi-Urban Driving Scenarios

Comparison between Conventional and Protective One-Lung Ventilation for Ventilator-Assisted Thoracic Surgery

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