Statistical analysis of inappropriate results from current Hb screening methods for blood donors

James, Veronica; Jones, Keith F.; Turner, Elizabeth M.; Sokol, Robert J.

doi:10.1046/j.1537-2995.2003.00316.x

Cited by 42 publications

(42 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inaccuracy in capillary haemoglobin could contribute to exacerbate the problem of donor rejection, and we and others have shown that many donors with acceptable haemoglobin concentration are inappropriately deferred under the conditions of routine fingerstick screening . Such imprecision may be related to analytical and non‐analytical factors such as the devices and procedures used for measurements, donor's posture for blood sampling, season of the year and intrinsic donor characteristics , but it can also be due to inherent differences between capillary and venous blood samples .…”

Section: Discussionmentioning

confidence: 99%

“…The determination of haemoglobin in a venous sample by an automatic haematological counter is the method of reference, but its use is not feasible in blood collection at mobile units. Portable haemoglobinometers are used worldwide for donor haemoglobin evaluation on the donor side, as they are fast, easy to use and provide a quantitative measurement within a wide range of haemoglobin concentrations . We have previously demonstrated that, in our routine working conditions, measurement of capillary haemoglobin with the HemoCue system is superior to the classical gravimetric test copper sulphate in detecting individuals with anaemia, but a significant proportion of donors with acceptable haemoglobin concentration are inappropriately rejected .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of two‐step haemoglobin screening with HemoCue for blood donor qualification in mobile collection sites

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of two‐step haemoglobin screening with HemoCue for blood donor qualification in mobile collection sites

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Hb estimation by this method though cheaper than the automated method takes more time [4]. In blood donations, the semi-quantitative gravimetric copper sulfate method which is very easy and inexpensive may be used, but does not provide an acceptable degree of accuracy [5,6]. The HemoCue ® Hb photometer has been widely used for these purposes in recent years [7] because it is portable, requires only a small sample of capillary/venous blood, is relatively inexpensive and simple to use, does not require access to refrigeration or even electricity, and gives immediate, digitally displayed results [3].…”

Section: Introductionmentioning

confidence: 99%

Hemoglobin estimation by the HemoCue® portable hemoglobin photometer in a resource poor setting

et al. 2011

View full text Add to dashboard Cite

BackgroundIn resource poor settings where automated hematology analyzers are not available, the Cyanmethemoglobin method is often used. This method though cheaper, takes more time. In blood donations, the semi-quantitative gravimetric copper sulfate method which is very easy and inexpensive may be used but does not provide an acceptable degree of accuracy. The HemoCue® hemoglobin photometer has been used for these purposes. This study was conducted to generate data to support or refute its use as a point-of-care device for hemoglobin estimation in mobile blood donations and critical care areas in health facilities.MethodEDTA blood was collected from study participants drawn from five groups: pre-school children, school children, pregnant women, non-pregnant women and men. Blood collected was immediately processed to estimate the hemoglobin concentration using three different methods (HemoCue®, Sysmex KX21N and Cyanmethemoglobin). Agreement between the test methods was assessed by the method of Bland and Altman. The Intraclass correlation coefficient (ICC) was used to determine the within subject variability of measured hemoglobin.ResultsOf 398 subjects, 42% were males with the overall mean age being 19.4 years. The overall mean hemoglobin as estimated by each method was 10.4 g/dl for HemoCue, 10.3 g/dl for Sysmex KX21N and 10.3 g/dl for Cyanmethemoglobin. Pairwise analysis revealed that the hemoglobin determined by the HemoCue method was higher than that measured by the KX21N and Cyanmethemoglobin. Comparing the hemoglobin determined by the HemoCue to Cyanmethemoglobin, the concordance correlation coefficient was 0.995 (95% CI: 0.994-0.996, p < 0.001). The Bland and Altman's limit of agreement was -0.389 - 0.644 g/dl with the mean difference being 0.127 (95% CI: 0.102-0.153) and a non-significant difference in variability between the two measurements (p = 0.843). After adjusting to assess the effect of other possible confounders such as sex, age and category of person, there was no significant difference in the hemoglobin determined by the HemoCue compared to Cyanmethemoglobin (coef = -0.127, 95% CI: -0.379 - 0.634).ConclusionHemoglobin determined by the HemoCue method is comparable to that determined by the other methods. The HemoCue photometer is therefore recommended for use as on-the-spot device for determining hemoglobin in resource poor setting.

show abstract

“…[9] Similarly Boulton et al . observed more inappropriate passes by CuSO 4 method with inappropriate passes being within 1.0 g/dl of the threshold for their gender.…”

Section: Discussionmentioning

confidence: 99%

Quality evaluation of four hemoglobin screening methods in a blood donor setting along with their comparative cost analysis in an Indian scenario

Tondon¹,

Verma²,

Pandey³

et al. 2009

Asian J Transfus Sci

View full text Add to dashboard Cite

Background:Despite the wide range of methods available for measurement of hemoglobin, no single technique has emerged as the most appropriate and ideal for a blood donation setup. Materials and Methods:A prospective study utilizing 1014 blood samples was carried out in a blood donation setting for quality evaluation of four methods of hemoglobin estimation along with cost analysis: Hematology cell analyzer (reference), HCS, CuSO4 method and HemoCue. Results:Mean value of HemoCue (mean ± SD = 14.7 ± 1.49 g/dl) was higher by 0.24 compared to reference (mean ± SD = 13.8 ± 1.52 g/dl) but not statistically significant ( P > 0.05). HemoCue proved to be the best technique (sensitivity 99.4% and specificity 84.4%) whereas HCS was most subjective with 25.2% incorrect estimations. CuSO4 proved to be good with 7.9% false results. Comparative cost analysis of each method was calculated to be 35 INR/test for HemoCue, 0.76 INR /test for HCS and 0.06-0.08 INR /test for CuSO4. Conclusion:CuSO4 method gives accurate results, if strict quality control is applied. HemoCue is too expensive to be used as a primary screening method in an economically restricted country like India.

show abstract

Statistical analysis of inappropriate results from current Hb screening methods for blood donors

Cited by 42 publications

References 14 publications

Evaluation of two‐step haemoglobin screening with HemoCue for blood donor qualification in mobile collection sites

Evaluation of two‐step haemoglobin screening with HemoCue for blood donor qualification in mobile collection sites

Hemoglobin estimation by the HemoCue® portable hemoglobin photometer in a resource poor setting

Quality evaluation of four hemoglobin screening methods in a blood donor setting along with their comparative cost analysis in an Indian scenario

Contact Info

Product

Resources

About