Statistical Analysis of<i>Hie</i>(Cold Sensation) and<i>Hiesho</i>(Cold Disorder) in Kampo Clinic

Yoshino, Tetsuhiro; Katayama, Kotoe; Munakata, Kaori; Horiba, Yuko; Yamaguchi, Rui; Imoto, Seiya; Miyano, Satoru; Watanabe, Kenji

doi:10.1155/2013/398458

Cited by 35 publications

(29 citation statements)

References 4 publications

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“…Kampo specialists from representative Universities and Kampo institutions in Japan (Keio University, Chiba University, Toyama University, Jichi Medical University, Tokyo Women's Medical University, Tohoku University, Kameda Medical Center, and Aso Iizuka Hospital) prepared the questionnaire after repeated discussions. Using this questionnaire, which comprises 128 binary questions, we collected information about our patients' subjective symptoms, as described in our previous report [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

The Difference between the Two Representative Kampo Formulas for Treating Dysmenorrhea: An Observational Study

Yoshino

Katayama

Horiba

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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In Kampo medicine, two different formulas are effective for treating dysmenorrhea—tokishakuyakusan and keishibukuryogan; however, the criteria by which specialists select the appropriate formula for each patient are not clear. We compared patients treated with tokishakuyakusan and those with keishibukuryogan and proposed a predictive model. The study included 168 primary and secondary dysmenorrhea patients who visited the Kampo Clinic at Keio University Hospital. We collected clinical data from 128 dysmenorrhea patients, compared the two patient groups and selected significantly different factors as potential predictors, and used logistic regression to establish a model. An external validation was performed using 40 dysmenorrhea patients. Lightheadedness, BMI < 18.5, and a weak abdomen were significantly more frequent in the tokishakuyakusan group; tendency to sweat, heat intolerance, leg numbness, a cold sensation in the lower back, a strong abdomen, and paraumbilical tenderness and resistance were more frequent in the keishibukuryogan group. The final model fitted the data well. Internally estimated accuracy was 81.2%, and a leave-one-out cross-validation estimate of accuracy was 80.5%. External validation accuracy was 85.0%. We proposed a model for predicting the use of two Kampo formulas for dysmenorrhea, which should be validated in prospective trials.

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Section: Methodsmentioning

confidence: 99%

The Difference between the Two Representative Kampo Formulas for Treating Dysmenorrhea: An Observational Study

Yoshino

Katayama

Horiba

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…We collected information about patients’ subjective symptoms using a questionnaire comprising 128 binary questions [11]. You can find all the items in Appendix: Tables 4 and 5.…”

Section: Methodsmentioning

confidence: 99%

Predicting Japanese Kampo formulas by analyzing database of medical records: a preliminary observational study

Yoshino

Katayama

Horiba

et al. 2016

BMC Med Inform Decis Mak

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BackgroundApproximately 90 % of physicians in Japan use Kampo medicine in daily practice. However, it is a challenge for physicians who do not specialize in Kampo medicine to select a proper Kampo formula out of the 148 officially approved formulas, as the decision relies on traditional measurements and traditional medicine pattern diagnoses. The present study tries to evaluate the feasibility of a decision support system for frequently used Kampo formulas.MethodsOur study included 393 patients who visited the Kampo Clinic at Keio University Hospital for the first time between May 2008 and March 2013. We collected medical records through a browser-based questionnaire system and applied random forests to predict commonly prescribed Kampo formulas.ResultsThe discriminant rate was the highest (87.0 %) when we tried to predict a Kampo formula from two candidates using age, sex, body mass index, subjective symptoms, and the two essential and predictable traditional medicine pattern diagnoses (excess–deficiency and heat–cold) as predictor variables. The discriminant rate decreased as the candidate Kampo formulas increased, with the greatest drop occurring between three (76.7 %) and four (47.5 %) candidates. Age, body mass index, and traditional medicine pattern diagnoses had higher importance according to the characteristics of each Kampo formula when we utilized the prediction model, which predicted a Kampo formula from among three candidates.ConclusionsThese results suggest that our decision support system for non-specialist physicians works well in selecting appropriate Kampo formulas from among two or three candidates. Additional studies are required to integrate the present statistical analysis in clinical practice.

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“…In Western medicine, hiesho is an unfamiliar concept but, in Oriental medicine, it is recognised as an important symptom of potential health problems. According to Yoshino et al (2013), hiesho is a common phenomenon in Japanese and traditional Chinese medicine; it is recognised as a condition that requires diagnosis and treatment. Hiesho is commonly experienced by…”

Section: Introductionmentioning

confidence: 99%

Is hiesho in pregnant women a risk factor for postpartum haemorrhage?

Nakamura¹,

Horiuchi²

2018

nzcomjnl

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Background: In Japanese culture, a cold sensation known as "hie" is an important symptom in traditional medicine. Hiesho is a condition whereby the sympathetic nervous system becomes dominant, causing peripheral blood vessels to contract, impairing circulation and leading to low skin temperatures in the extremities. A link between hiesho and prolonged labour and uterine inertia, both of which are risk factors for postpartum haemorrhage (PPH), has previously been identified. Aim: The aim of this study was to analyse whether hiesho has a direct impact on PPH by comparing the outcomes for women who experienced hiesho in their pregnancies with those who did not. Methods: The study design was a retrospective cohort study conducted over 12 months, between 19th October, 2009, and 8th October, 2010, involving 2,427 women who had given birth in six hospitals in Japan. Women were excluded if they had had a caesarean section. Data were extracted from medical records and a paper questionnaire. Analysis was conducted using multiple logistic regression analysis and the Mantel-Haenszel test. Findings: Of the women, 613 experienced PPH (25.3% of the entire sample), of whom 343 (56.0%) had experienced hiesho. In the analysis of covariance, the regression coefficient for hiesho was 0.2, p=0.07, the odds ratio (OR) was 1.22, and the 95% confidence interval (CI) was 0.98-1.50. In a stratified analysis, the regression coefficient was 0.25, p=0.02, the common OR was 1.29, and 95% CI was 1.04-1.59. Thus, there was no significant link found between a woman experiencing heisho during pregnancy and having a PPH. Conclusion: Although the findings indicate that uterine inertia and prolonged labour are direct causes of PPH, hiesho may potentially have an indirect effect. Therefore, since hiesho potentially affects the occurrence of uterine inertia and prolonged labour, preventing hiesho may help avoid uterine inertia and prolonged labour and consequently PPH. For women who experience hiesho in pregnancy, lifestyle activities known to improve peripheral circulation should be promoted antenatally.

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Statistical Analysis ofHie(Cold Sensation) andHiesho(Cold Disorder) in Kampo Clinic

Cited by 35 publications

References 4 publications

The Difference between the Two Representative Kampo Formulas for Treating Dysmenorrhea: An Observational Study

The Difference between the Two Representative Kampo Formulas for Treating Dysmenorrhea: An Observational Study

Predicting Japanese Kampo formulas by analyzing database of medical records: a preliminary observational study

Is hiesho in pregnant women a risk factor for postpartum haemorrhage?

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