Statistical Analysis of High Frequency Ultrasonic Backscattered Signals from Basal Cell Carcinomas

Petrella, Lorena; Valle, Heliomar de Azevedo; Issa, P.R.; Martins, Carlos José; Machado, João Carlos; Pereira, Wagner Coelho de Albuquerque

doi:10.1016/j.ultrasmedbio.2012.06.001

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…They are typically surrounded by collagen fibres. The progressive cancer stage is represented by reduced stroma in the dermis along with the enlarged tumour nests . These clusters present various histological types of BCC depending on the different configuration of atypical cells.…”

Section: Resultsmentioning

confidence: 99%

High‐resolution quantitative acoustic microscopy of cutaneous carcinoma and melanoma: Comparison with histology

Youssef

Seviaryna

Shum

et al. 2019

Skin Research and Technology

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Background The increased incidence rate of skin cancers during the last decades is alarming. One of the significant difficulties in the histopathology of skin cancers is appearance variability due to the heterogeneity of diseases or tissue preparation and staining process. This study aims to investigate whether the high‐resolution acoustic microscopy has the potential for identifying and quantitatively classifying skin cancers. Material/Methods Unstained standard formalin‐fixed skin tissue samples were used for ultrasonic examination. The high‐frequency acoustic microscope equipped with the 320 MHz transducer was utilized to visualize skin structure. Fourier transform was performed to calculate the sound speed and attenuation in the tissue. Results The acoustic images demonstrate good concordance with the traditional histology images. All histological features in the tumour were easily identifiable on acoustic images. Each skin cancer type has its combination of ultrasonic properties significantly different from the healthy skin. Conclusions High‐resolution acoustic imaging strengthened with quantitative analysis shows a potential to work as an auxiliary imaging modality assisting pathologists to lean to the particular decision in doubtful cases. The method can also assist surgeon to ensure the complete resection of a tumour.

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Section: Resultsmentioning

confidence: 99%

High‐resolution quantitative acoustic microscopy of cutaneous carcinoma and melanoma: Comparison with histology

Youssef

Seviaryna

Shum

et al. 2019

Skin Research and Technology

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“…The statistical literature contains a large number of probabilistic models that could be applied to fitting the corneal OCT speckle. So far, our study has focused on the most common models which have been used to fit light or ultrasound speckle such as, Generalized Gamma (GG) [23,33,34], Gamma (G) [35], Weibull (W) [33,34], Nakagami (N) [20,34], Rayleigh (R) [34], K-Distribution (K) [34], Rician (Ri) [34] and Lognormal distribution (L) [36].…”

Section: Speckle Modelingmentioning

confidence: 99%

Assessment of corneal properties based on statistical modeling of OCT speckle

Jesus¹,

Iskander²

2016

Biomed. Opt. Express

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A new approach to assess the properties of the corneal micro-structure based on the statistical modeling of speckle obtained from Optical Coherence Tomography (OCT) is presented. A number of statistical models were proposed to fit the corneal speckle data obtained from OCT raw image. Short-term changes in corneal properties were studied by inducing corneal swelling whereas age-related changes were observed analyzing data of sixty-five subjects aged between twenty-four and seventy-three years. Generalized Gamma distribution has shown to be the best model, in terms of the Akaike's Information Criterion, to fit the OCT corneal speckle. Its parameters have shown statistically significant differences (Kruskal-Wallis, < 0.001) for short and age-related corneal changes. In addition, it was observed that age-related changes influence the corneal biomechanical behaviour when corneal swelling is induced. This study shows that Generalized Gamma distribution can be utilized to modeling corneal speckle in OCT providing complementary quantified information where micro-structure of corneal tissue is of essence.

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“…In the present study, we mainly aim to describe the current application of high-frequency US in the diagnosis of PBM and associated morphological findings in our pediatric center. Because of its higher resolution (16–158 μm) compared with ordinary ultrasound, high-frequency US was recognized as the ultrasound biomedical microscope ( 14 , 15 ). In our investigation, its imaging qualities allow us clearly obtain the structure and thickness of ducts, channel, and gallbladder.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of the Accuracy of High-Frequency Ultrasound for Pancreaticobiliary Maljunction in Pediatrics at a Single Center

Liu

et al. 2022

Front. Pediatr.

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ObjectiveTo determine the clinical value of high-frequency ultrasonography (US) in the evaluation and diagnosis of pancreaticobiliary maljunction (PBM) among children.MethodsThe clinical subjects consisted of 31 pediatric patients who were diagnosed with PBM from January 2015 to May 2021 in Fujian Provincial Maternity and Children's Hospital. The primary outcomes included diagnosis accuracy, imaging characteristics of each type of PBM based on JSPBM, time length of operation, and cost of service. Secondary outcomes were the serum amylase and bilirubin levels.ResultsThe diagnostic accuracy of US was 90.3% and comparable to the other imaging methods—MRCP (82.6%), IOC (79.2%), and ERCP (100%), respectively. The time length of operation and direct cost were significantly lower than other imaging pathways. Stenotic type (A) is associated with a high internal diameter of CBD, and dilated channel type (C) presents increased internal diameter and length of CC as well as internal diameter of PD. There were higher levels of the serum bilirubin seen in type A and of serum amylase in type C compared with others.ConclusionHigh-frequency US is a safe, cost-effective, and non-invasive imaging tool for the diagnosis and evaluation of PBM in pediatrics.

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Statistical Analysis of High Frequency Ultrasonic Backscattered Signals from Basal Cell Carcinomas

Cited by 10 publications

References 24 publications

High‐resolution quantitative acoustic microscopy of cutaneous carcinoma and melanoma: Comparison with histology

High‐resolution quantitative acoustic microscopy of cutaneous carcinoma and melanoma: Comparison with histology

Assessment of corneal properties based on statistical modeling of OCT speckle

Retrospective Analysis of the Accuracy of High-Frequency Ultrasound for Pancreaticobiliary Maljunction in Pediatrics at a Single Center

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