Statistical Analysis of Coding for Molecular Properties in the Olfactory Bulb

Auffarth, Benjamin; Gutiérrez-Gálvez, A.; Marco, S.

doi:10.3389/fnsys.2011.00062

Cited by 8 publications

(15 citation statements)

References 36 publications

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“…We found a good representation of our data with nine bulb regions, called modules. These modules show some analogy to previously reported regional structures in the bulb [5] [6]. Furthermore, we demonstrate a linkage between typical odorant characteristics and our modules, so this speaks in favour of a chemotopic coding map in the bulb.…”

supporting

confidence: 51%

Analysis of the coding scheme in the olfactory bulb with NMF

Wegner

Mamlouk

2014

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supporting

confidence: 51%

Analysis of the coding scheme in the olfactory bulb with NMF

Wegner

Mamlouk

2014

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“…Our results from a systematic largescale study of glomerular activity indicated that coding of some molecular properties, including functional groups and chemical bonds, is organized in continuous zones and locally restricted (Auffarth et al, 2011a). Furthermore, the relative spatial locations between representational areas corresponding to odorant categories could be related to chemical similarity Ma et al, 2012;Auffarth et al, 2011a;Johnson et al, 2004).…”

Section: Physiologymentioning

confidence: 99%

“…Auffarth et al, 2011a;Matsumoto et al, 2010). It therefore seems plausible that lateral processing in the olfactory system makes use of a topographic organization.…”

Section: Physiologymentioning

confidence: 99%

“…Furthermore, the relative spatial locations between representational areas corresponding to odorant categories could be related to chemical similarity Ma et al, 2012;Auffarth et al, 2011a;Johnson et al, 2004). This principle has been referred to as chemotopy or, spatial progression, in the case of a spatial shift related to molecular properties.…”

Section: Physiologymentioning

confidence: 99%

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Understanding smell—The olfactory stimulus problem

Auffarth

2013

Neuroscience & Biobehavioral Reviews

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Please cite this article as: Auffarth, B., Understanding smell -the olfactory stimulus problem, Neuroscience and Biobehavioral Reviews (2013), http://dx.doi.org/10.1016/j.neubiorev.2013.06.009. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 27 A c c e p t e d M a n u s c r i p t -For the olfactory system, a topographic organization is disputed. -However, work on different species suggests a topography in olfaction.-We compare other modalities such as taste and color vision.-We discuss the utility of a categorization of smell perception. *Highlights (for review)Page 2 of 27 A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 Neuroscience and Biobehavioral Reviews The main problem with sensory processing is the difficulty in relating sensory input to physiological responses and perception. This is especially problematic at higher levels of processing, where complex cues elicit highly specific responses. In olfaction, this relationship is particularly obfuscated by the difficulty of characterizing stimulus statistics and perception. The core questions in olfaction are hence the so-called stimulus problem, which refers to the understanding of the stimulus, and the structure-activity and structure-odor relationships, which refer to the molecular basis of smell. It is widely accepted that the recognition of odorants by receptors is governed by the detection of physico-chemical properties and that the physical space is highly complex. Not surprisingly, ideas differ about how odor stimuli should be classified and about the very nature of information that the brain extracts from odors. Even though there are many measures for smell, there is none that accurately describes all aspects of it. Here, we summarize recent developments in the understanding of olfaction. We argue that an approach to olfactory function where information processing is emphasized could contribute to a high degree to our understanding of smell as a perceptual phenomenon emerging from neural computations. Further, we argue that combined analysis of the stimulus, biology, physiology, and behavior and perception can provide new insights into olfactory function. We hope that the reader can use this review as a competent guide and overview of research activities in olfactory physiology, psychophysics, computation, and psychology. We propose avenues for research, particularly in the systematic characteriza...

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“…Evidence is now accumulating of behavioral relevance of molecular feature combinations and glomerular domains (e.g., Dielenberg and McGregor, 2001; Kobayakawa et al, 2007; Raman and Gutierrez-Osuna, 2009; Sakano, 2010). It has also been shown that perceptual differences can be predicted by glomerular spatial activity patterns (Uchida et al, 2000; Linster et al, 2001; Auffarth et al, 2011a). …”

Section: Introductionmentioning

confidence: 99%

Map Formation in the Olfactory Bulb by Axon Guidance of Olfactory Neurons

Auffarth¹,

Kaplan²,

Lansner³

2011

Front. Syst. Neurosci.

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The organization of representations in the brain has been observed to locally reflect subspaces of inputs that are relevant to behavioral or perceptual feature combinations, such as in areas receptive to lower and higher-order features in the visual system. The early olfactory system developed highly plastic mechanisms and convergent evidence indicates that projections from primary neurons converge onto the glomerular level of the olfactory bulb (OB) to form a code composed of continuous spatial zones that are differentially active for particular physico-chemical feature combinations, some of which are known to trigger behavioral responses. In a model study of the early human olfactory system, we derive a glomerular organization based on a set of real-world, biologically relevant stimuli, a distribution of receptors that respond each to a set of odorants of similar ranges of molecular properties, and a mechanism of axon guidance based on activity. Apart from demonstrating activity-dependent glomeruli formation and reproducing the relationship of glomerular recruitment with concentration, it is shown that glomerular responses reflect similarities of human odor category perceptions and that further, a spatial code provides a better correlation than a distributed population code. These results are consistent with evidence of functional compartmentalization in the OB and could suggest a function for the bulb in encoding of perceptual dimensions.

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Statistical Analysis of Coding for Molecular Properties in the Olfactory Bulb

Cited by 8 publications

References 36 publications

Analysis of the coding scheme in the olfactory bulb with NMF

Analysis of the coding scheme in the olfactory bulb with NMF

Understanding smell—The olfactory stimulus problem

Map Formation in the Olfactory Bulb by Axon Guidance of Olfactory Neurons

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