Stationary phase complexation of polyethers: Separation of polyethers with amino-bonded silica gel

A refined one-filtration method for aqueous based nanofiltration and ultrafiltration membrane molecular weight cut-off determination using polyethylene glycols

“…Successful PEG separations have been achieved with the more expensive techniques of size exclusion chromatography (more specifically gel permeation chromatography, GPC) [2], higher temperature (80 o C) multi-column reverse phase high performance liquid chromatography (HPLC) and supercritical fluid chromatography [7], capillary gel electrophoresis [36], liquid chromatography coupled with mass spectroscopy (LC-MS) [34] and ion exchange chromatography [37]. There are many disadvantages with these methods however.…”

“…Capillary gel electrophoresis allows the separation and quantification of PEGs with MWs up to thousands of Daltons, but requires time-consuming sample preparation by derivatization [36] making this method less attractive for large scale analysis compared to the other methods. Ion exchange chromatography has been used in the separation of PEG derivatives [37], however the preparation and refining of the method is relatively complicated since PEGs are non-polar and have non-ionized sites.…”