Statins Should Be Used with Greater Caution in Patients Undergoing Thyroid Hormone Withdrawal for Radioactive Iodine Treatment

Al‐Salameh, Abdallah; Bihan, H.; Keller-Petrot, Isabelle; Reach, Gérard; Dhôte, Robin; Cohen, R.

doi:10.1089/thy.2010.0317

Cited by 2 publications

(4 citation statements)

References 4 publications

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“…Given that patients with hypothyroidism have been excluded from statin clinical trials there are limited data regarding the incidence of statin muscle toxicity in patients with hypothyroidism [92][93][94][95][96][97]. In hypothyroid patients, myopathy with mild elevation of serum CK activity is not rare and in a few cases might take the form of overt rhabdomyolysis even in patients not on statin treatment.…”

Section: Thyroid Diseases and Statin Intolerancementioning

confidence: 99%

“…In hypothyroid patients, myopathy with mild elevation of serum CK activity is not rare and in a few cases might take the form of overt rhabdomyolysis even in patients not on statin treatment. However, if statin treatment is added it seems that the risk of muscle-related side effects increases markedly [91][92][93][94][95][96][97]. It is therefore recommended that a clinical examination, thyroid-stimulating hormone (TSH) and thyroxine levels measurement should be performed before statin treatment initiation.…”

Section: Thyroid Diseases and Statin Intolerancementioning

confidence: 99%

See 1 more Smart Citation

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Banach

Rizzo²,

Tóth

et al. 2015

Expert Opinion on Drug Safety

181

204

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Section: Thyroid Diseases and Statin Intolerancementioning

confidence: 99%

Section: Thyroid Diseases and Statin Intolerancementioning

confidence: 99%

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Banach

Rizzo²,

Tóth

et al. 2015

Expert Opinion on Drug Safety

181

204

View full text Add to dashboard Cite

“…Given that patients with hypothyroidism have been excluded from statin clinical trials there are limited data regarding the incidence of statin muscle toxicity in patients with hypothyroidism [ 92 – 97 ]. In hypothyroid patients, myopathy with mild elevation of serum CK activity is not rare and in a few cases might take the form of overt rhabdomyolysis even in patients not on statin treatment.…”

Section: Conditions and Populations At High Risk Of Statin Intolerancmentioning

confidence: 99%

“…In hypothyroid patients, myopathy with mild elevation of serum CK activity is not rare and in a few cases might take the form of overt rhabdomyolysis even in patients not on statin treatment. However, if statin treatment is added it seems that the risk of muscle-related side effects increases markedly [ 91 – 97 ]. It is therefore recommended that a clinical examination, thyroid-stimulating hormone (TSH) and thyroxine levels measurement should be performed before statin treatment initiation.…”

Section: Conditions and Populations At High Risk Of Statin Intolerancmentioning

confidence: 99%

Position paper Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Banach¹,

Rizzo²,

Tóth³

et al. 2015

aoms

325

206

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Statins are one of the most commonly prescribed drugs in clinical practice. They are usually well tolerated and effectively prevent cardiovascular events. Most adverse effects associated with statin therapy are muscle-related. The recent statement of the European Atherosclerosis Society (EAS) has focused on statin associated muscle symptoms (SAMS), and avoided the use of the term ‘statin intolerance’. Although muscle syndromes are the most common adverse effects observed after statin therapy, excluding other side effects might underestimate the number of patients with statin intolerance, which might be observed in 10–15% of patients. In clinical practice, statin intolerance limits effective treatment of patients at risk of, or with, cardiovascular disease. Knowledge of the most common adverse effects of statin therapy that might cause statin intolerance and the clear definition of this phenomenon is crucial to effectively treat patients with lipid disorders. Therefore, the aim of this position paper was to suggest a unified definition of statin intolerance, and to complement the recent EAS statement on SAMS, where the pathophysiology, diagnosis and the management were comprehensively presented.

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Statins Should Be Used with Greater Caution in Patients Undergoing Thyroid Hormone Withdrawal for Radioactive Iodine Treatment

Cited by 2 publications

References 4 publications

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Position paper Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

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