Statins for primary prevention of venous thromboembolism

Li, Lun; Zhang, Peizhen; Tian, Jin Hui; Yang, Kehu

doi:10.1002/14651858.cd008203.pub3

Cited by 16 publications

(1 citation statement)

References 89 publications

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“…In this regard, “maintenance of ideal cardiovascular health” is associated with lower D-dimer [19] and reduced VTE incidence [21, 22], and may be one strategy to reduce the large public health burden of VTE. Use of statins also can lower D-dimer [23] but whether they reduce VTE remains controversial [24]. …”

Section: Discussionmentioning

confidence: 99%

Prospective study of plasma D-dimer and incident venous thromboembolism: The Atherosclerosis Risk in Communities (ARIC) Study

Folsom

Alonso

George

et al. 2015

Thrombosis Research

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Introduction Plasma D-dimer is a useful clinical test for acute venous thromboembolism (VTE), and concentrations remain higher in VTE patients after treatment than in controls. Yet, evidence is limited on whether higher basal D-dimer concentrations in the general population are associated with greater risk of first VTE. Objective To assess the prospective association between D-dimer and incident VTE over a long follow-up. Methods We measured plasma D-dimer in 12,097 participants, initially free of VTE, in the Atherosclerosis Risk in Communities Study. Over a median follow-up of 17 years, we identified 521 VTEs. We calculated hazard ratios of VTE using proportional hazards regression. Results The age, race, and sex adjusted hazard ratios of VTE across quintiles of D-dimer were 1, 1.5, 1.8, 2.1, and 3.2 (p for trend <0.0001). For the first 10 years of follow-up, the hazard ratio for the highest versus lowest quintile was 3.5, and was 2.9 after 10 years. In both whites and African Americans, VTE risk remained strongly associated with D-dimer after further adjustment for diabetes, body mass index, kidney function, and several thrombophilia genetic markers. D-dimer was associated with both unprovoked and provoked VTE, but more strongly with unprovoked. Conclusions A higher basal level of plasma D-dimer in the general population, presumably reflecting a predisposition to thrombosis, is a strong, long-term risk factor for a first VTE.

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