Statins for Preventing Venous Thrombosis: For or Against?

Lingering effects of COVID-19 in the care of perioperative patients

“…J Clin Anesth 2023; 89:111182. This study reveals that COVID-19 positive test is associated with a higher risk of all-cause mortality following ambulatory surgery, with the greatest risk being in the first45 days. 5.…”

“…Clinically, macrovascular and microvascular thrombosis following COVID-19 may affect every organ system, and "thromboinflammation" has been proposed as a unifying mechanism of many lingering sequelae of COVID-19 infection [44 && ]. Elevated thrombotic risk has been observed during and after SARS-CoV-2 infection, and across disease severity spectrum [45]. Notably, a case series from Singapore reported severe large vessel ischemic strokes and aortic valve thrombosis in four young and otherwise healthy patients, at a median timepoint of 78 days following COVID-19 diagnosis [46], and multiple observational studies have identified an association between COVID-19 infection and acute limb ischemia [47].…”

Antisense lipoprotein[a] therapy: State-of-the-art and future perspectives

“…A different strategy shall be planned instead in patients with concomitant elevations of Lp[a] and LDL. In these patients, either combining the two apo[a] and apoB antisense therapies (a strategy which has never been tested, however), or the combination of well-known and relatively inexpensive drugs such as statins with antisense apo[a] inhibitors [61] or the use of a dual therapy based on antisense apo[a] inhibitors and well-known and relatively inexpensive drugs such the statins [62] can be theoretically suggested.…”

Editorial Compilation XIV

“…The last review in this issue of STH is by two of the guest editors, Giuseppe Lippi and Emmanuel Favaloro, who provide a concise review on the epidemiology and predisposing factors of post-COVID venous thrombosis. 10 As previously reported, STH has previously published a series of issues around the theme of maintaining hemostasis and preventing thrombosis in COVID-19, with the final such issue published in early 2023. 11 As the international emergency for COVID-19 has been withdrawn by the World Health Organization, and we start to return to “business as usual,” we are no longer publishing COVID-19 themed issues, and instead any COVID-19-related material accepted for publication will now appear in the other compilation themes in progress, such as the Editorial Compilation series ( Table 1 ).…”