Statins decrease leptin expression in human white adipocytes

Abstract

Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake. However, increases in calorie intake in statin users may also be related to statin‐dependent decreases in satiety factors such as leptin, an adipocyte‐derived adipokine. The objective of our study was to examine the direct effects of statins on leptin expression. Adipocytes are the main source of circulating leptin. Therefore, we examined the effects of atorvastatin and simvastatin on leptin expression in cultured human white adipocytes. We show that treatment of white adipocytes with simvastatin and atorvastatin decreases leptin mRNA expression (simvastatin: P = 0.008, atorvastatin: P = 0.03) and leptin secretion (simvastatin: P = 0.0001, atorvastatin: P = 0.0001). Both simvastatin and atorvastatin mediate decreases in leptin expression via extracellular‐signal‐regulated kinases 1/2 and peroxisome proliferator‐activated receptor gamma pathways (simvastatin: P = 0.01, atorvastatin: P = 0.026). Additionally, statin treatment also induced expected increases in adiponectin, while decreasing monocyte chemoattractant protein 1 (MCP1) mRNA. Furthermore, statins increased secretion of both total as well as high molecular weight adiponectin while decreasing MCP1 secretion. To conclude, statins act directly on human white adipocytes to regulate adipokine secretion and decrease leptin expression. Leptin is an important satiety factor. Hence, statin‐dependent decreases in leptin may contribute, at least in part, to increases in food intake in statin users.

Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men

“…Some classes of drugs may affect both LPT and SUA levels. LPT is reduced by the administration of antidiabetic therapy [45,46,47,48,49] or statins [50]. While, SUA may be affected by antihypertensive drugs [51].…”

Serum Levels and Adipose Tissue Gene Expression of Cathelicidin Antimicrobial Peptide (CAMP) in Obesity and During Weight Loss

“…Expression levels of the target gene were normalized to the gene expression of GAPDH as a house keeping gene as done by other experienced groups [16]. The primer-pairs used were: 5′-TGTC-CGTCGTGGATCTGAC-3′/5′-AGGGAGATGCTCAGTGTTGG-3′ (mouse), 5′-GAGTCC AC TGGCGTC T TC AC-3′/5′-CC AGGG-GTGCTAAGCAGTT-3′ (human).…”

Parathyroid Hormone and 25-Hydroxyvitamin D Do Not Mediate the Association between Dietary Calcium, Protein and Vitamin D Intake and Adiposity and Lipid Profile in Patients with Type 2 Diabetes: a Structural Equation Modeling Approach

“…It has been observed that increased levels of insulin in the blood are associated with an increase in serum LDL-C and TG but decrease in serum HDL-C levels [ 30 34 ]. So, in many diabetic patients, lipid and cholesterol-lowering medications such as statins and fibrates are used to reduce blood lipids that are associated with lower levels of leptin in the blood [ 35 ]. Dietary calcium also increases the production of adiponectin in overweight and obese individuals [ 36 37 ].…”