Statins attenuate hyperalgesia and inflammation in experimentally induced acute and neuropathic pain in rats

Kamel, Elsayed; Elsaid, Ahmed F.; Gumaa, Eid A; Sheweal, Abd Elhafez M El

doi:10.4103/1687-7934.189562

Cited by 2 publications

(1 citation statement)

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“…The role of statins in influencing pain is not yet fully clear. Attenuation of thermal hyperalgesia in an animal model of neuropathic pain, induced by partial ligation of the sciatic nerve, was independent on the statin-induced hypolipidemic effect [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Objective Evaluation of Chronic Low-Back Pain Using Serum Lipids: The Role of the Doctor-Patient Relationship

Bruthans

Vranová

Yamamotová

2023

Pain Research and Management

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Statistical data show that pain intensity in patients with low back pain is associated with a higher BMI, total serum cholesterol, and triacylglycerol levels. The objective of our study was to evaluate how these associations are dependent on the nature of the patient-doctor relationship. Eighty-nine patients hospitalized with chronic low-back pain (50 women, 39 men; average age: 64.5 ± 12.7 years) were assessed over a 3-year period. A serum lipid analysis was conducted (LDL-C, HDL-C, and total cholesterols) at admission in parallel with a subjective evaluation of pain intensity, which was assessed using a numeric rating scale. The participating physician assigned, based on their personal interaction with the patient, an attribute of affinity (positive, neutral, and negative) towards them. Current serum lipid levels and pain intensity were correlated relative to these attributes. Pain intensity did not differ between the groups assigned positive or negative attributes of affinity. In patients belonging to the “positive” group, pain intensity correlated positively with total cholesterol ( p = 0.01 ) and LDL cholesterol ( p = 0.007 ). No correlations were found in the “negative” group or when the patient-doctor relationship was ignored. We found a significant association between subjectively assessed low back pain intensity and serum levels of total and LDL cholesterol in patients with whom the physician had a positive affinity. A positive affinity with the patients having chronic pain and the patient’s trust in their physicians may ultimately mean that the patient’s statement about pain is more credible, which may retroactively affect the outcome of therapy.

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Section: Discussionmentioning

confidence: 99%

Objective Evaluation of Chronic Low-Back Pain Using Serum Lipids: The Role of the Doctor-Patient Relationship

Bruthans

Vranová

Yamamotová

2023

Pain Research and Management

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Standardized study of atorvastatin possible osteoarthritis disease‐modifying effect in a rat model of osteoarthritis

Gaballah

Genedy

Ghayaty

et al. 2021

Fundamemntal Clinical Pharma

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We studied the osteoarthritis (OA)-modifying effects of atorvastatin in an experimental OA rat model and possible underlining mechanisms. We used 62 adult male Sprague-Dawley rats (250-300 g): 32 rats were used to assess the effects of atorvastatin on surgically induced OA in the knee, and 30 rats were used to assess the potential inflammatory effects of carrageenan-induced paw edema. In the OA model, joint stiffness was assessed by measuring the knee extension angle, and pathological changes in the OA knee joint were determined by histological examination and the measurement of serum biochemical markers, including interleukin-1β (IL-1β), matrix metalloproteinase-13 (MMP-13), and reduced glutathione (GSH). In the carrageenan-induced paw edema model, both paw thickness and pain threshold were assessed in different groups. Atorvastatin significantly improved joint stiffness, pathological changes, a significant mitigation of the higher MMP-13 and IL-1β, and a significant increase of reduced GSH in OA rats. Additionally, atorvastatin significantly improved both paw thickness and pain threshold in animals. Atorvastatin is a potential OA-modifying drug that warrants further clinical investigation.

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Statins attenuate hyperalgesia and inflammation in experimentally induced acute and neuropathic pain in rats

Cited by 2 publications

References 0 publications

Objective Evaluation of Chronic Low-Back Pain Using Serum Lipids: The Role of the Doctor-Patient Relationship

Objective Evaluation of Chronic Low-Back Pain Using Serum Lipids: The Role of the Doctor-Patient Relationship

Standardized study of atorvastatin possible osteoarthritis disease‐modifying effect in a rat model of osteoarthritis

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