Statins and the Risk of Cirrhosis in Chronic Hepatitis B Patients

Reduced risk of decompensation and death associated with use of statins in patients with alcoholic cirrhosis. A nationwide case‐cohort study

“…With this method we found an association between mortality and the constancy by which statins were claimed by the patients. Our results are in concordance with earlier retrospective studies of patients with cirrhosis due to chronic HBV or HCV infection with regard to the association between statin use and mortality and decompensation, In the study by Huang et al a dose‐response association was reported but the results were severely hampered by immortal time bias . Nevertheless, none of the previously published retrospective studies matched the patients using time from diagnosis to initiation of statins.…”

“…Our results are in concordance with earlier retrospective studies of patients with cirrhosis due to chronic HBV or HCV infection with regard to the association between statin use and mortality and decompensation, 8,9 In the study by Huang et al 8 a dose-response association was reported but the results were severely hampered by immortal time bias. 19 Nevertheless, none of the previously published retrospective studies matched the patients using time from diagnosis to initiation of statins. A possible mechanism behind the observed relationship between use of statins and mortality may be due to a lower risk of infections.…”