Statins and Stroke

Chaudhari, Dinesh; Renjen, Pushpendra Nath; Memon, Mahir

doi:10.1016/j.apme.2016.02.008

Cited by 1 publication

(4 citation statements)

References 14 publications

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“…These results were mirrored by an additional study showing a consistent 17%-21% reduction in incident stroke risk when patients were put on a statin regimen. 154 A multitude of recent experimental studies [156][157][158] have pointed to a decrease in mortality risk with statin therapy when rendered both before and after the onset of stroke. 159 This decline in mortality risk may be attributed to the neuroprotective and neurorestorative effects of statins during the onset of an ischemic stroke and after, respectively.…”

Section: Lipid Insights 2016:9mentioning

confidence: 99%

“…153 The inherent heterogeneity in the disease may be the likely culprit of these inconsistencies, as stroke has various etiologies. 154 However, it has been shown that statin-induced reduction in cholesterol concentrations decreases the risk of stroke in high-risk patient populations (ie, those with established coronary artery disease, hypertension, diabetes, or a high vascular risk). 154,155 A meta-analysis 155 revealed that each 1 mM decrease in LDL cholesterol compared to a 21.1% overall reduction in the relative risk for stroke.…”

Section: Emerging Therapeutic Applications Of Statinsmentioning

confidence: 99%

“…154 However, it has been shown that statin-induced reduction in cholesterol concentrations decreases the risk of stroke in high-risk patient populations (ie, those with established coronary artery disease, hypertension, diabetes, or a high vascular risk). 154,155 A meta-analysis 155 revealed that each 1 mM decrease in LDL cholesterol compared to a 21.1% overall reduction in the relative risk for stroke. These results were mirrored by an additional study showing a consistent 17%–21% reduction in incident stroke risk when patients were put on a statin regimen.…”

Section: Emerging Therapeutic Applications Of Statinsmentioning

confidence: 99%

“…These results were mirrored by an additional study showing a consistent 17%–21% reduction in incident stroke risk when patients were put on a statin regimen. 154…”

Section: Emerging Therapeutic Applications Of Statinsmentioning

confidence: 99%

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Current and Emerging Uses of Statins in Clinical Therapeutics: A Review

et al. 2016

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Statins, a class of cholesterol-lowering medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, are commonly administered to treat atherosclerotic cardiovascular disease. Statin use may expand considerably given its potential for treating an array of cholesterol-independent diseases. However, the lack of conclusive evidence supporting these emerging therapeutic uses of statins brings to the fore a number of unanswered questions including uncertainties regarding patient-to-patient variability in response to statins, the most appropriate statin to be used for the desired effect, and the efficacy of statins in treating cholesterol-independent diseases. In this review, the adverse effects, costs, and drug–drug and drug–food interactions associated with statin use are presented. Furthermore, we discuss the pleiotropic effects associated with statins with regard to the onset and progression of autoimmune and inflammatory diseases, cancer, neurodegenerative disorders, strokes, bacterial infections, and human immunodeficiency virus. Understanding these issues will improve the prognosis of patients who are administered statins and potentially expand our ability to treat a wide variety of diseases.

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Section: Lipid Insights 2016:9mentioning

confidence: 99%

Section: Emerging Therapeutic Applications Of Statinsmentioning

confidence: 99%

Section: Emerging Therapeutic Applications Of Statinsmentioning

confidence: 99%

“…These results were mirrored by an additional study showing a consistent 17%–21% reduction in incident stroke risk when patients were put on a statin regimen. 154…”

Section: Emerging Therapeutic Applications Of Statinsmentioning

confidence: 99%

See 2 more Smart Citations