Statins and prostate cancer recurrence following radical prostatectomy or radiotherapy: a systematic review and meta-analysis

Abstract

Our meta-analysis suggests a potentially beneficial effect of statins on prostate cancer patients treated with RT but not among radical prostatectomy patients. Although limited by the lack of randomized data, these results suggest that primary treatment modality should be considered in future studies examining associations between statins and oncologic outcomes.

Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy

“…This observation is in line with five previously published studies [11][12][13][14][15] and a recent meta-analysis, 19 which could not reveal a significant association of statin use with BCR after RP. In contrast, Ritch et al detected an increased risk of BCR in PC patients using statins after RP.…”

“…In addition, 20% of the patients in the study Statins use and prostate cancer outcomes M Rieken et al As studies and meta-analyses have shown a beneficial effect of statins in PC patients undergoing radiotherapy, the high rate of patients with radiotherapy might have influenced study results in this subgroup. 19 To explore the influence of clinicopathologic features on the association of statin use with outcomes after RP, we performed a subgroup analysis. In our analysis, BCR-free survival did not show any significant difference between statin users and non-users in patients when categorizing according to Gleason sum (p 6; ¼ 7; X8) without PSM, with stage pT3a and pT3b, and with lymph node metastasis.…”

Statin Use and Survival from Lung Cancer: A Population-Based Cohort Study

“…Preclinical studies have proposed a number of relevant biologic mechanisms, including inhibition of cell proliferation, stimulation of anticancer immune surveillance, and interruption of oncogenic signaling (2). In humans, epidemiologic studies have shown reductions in cancer recurrence or cancer-specific mortality at a number of cancer sites, including breast (5), prostate (6), and colorectal (7).…”

Clinical Potential of Statins in Prostate Cancer Radiation Therapy

“…Among men who underwent radiation therapy as the primary treatment, statin users had a statistically significant lower risk of recurrence compared with non-users (HR=0.68; 95% CI=0.49-0.93) (44). There was also no impact of statin use on overall survival (p=0.62 by log-rank test).…”

“…The Park et al meta-analysis suggested that statin use did not affect recurrence-free survival based on six randomised control trials (44). Statin use does not have an impact on prostate cancer specific survival (PCSS) on multivariate analysis (45).…”