Statiner og amming ved familiær hyperkolesterolemi

Holmsen, Solveig T.; Bakkebø, Tina; Seferowicz, Maria; Retterstøl, Kjetil

doi:10.4045/tidsskr.16.0838

Cited by 8 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 3 Theoretically, rosuvastatin may be more suitable for use in breastfeeding than other statins as it has a relatively large molecular weight (1,001.14 g/mol), a higher degree of protein binding (90%) and a higher volume of distribution compared with other statins. 3 , 4 In addition, rosuvastatin has a pKa of 4.6 and is considered to be a hydrophilic statin. The use of cholesterol-lowering medications during breastfeeding is currently not recommended due to potential adverse effects on the breastfed infant.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations

Lwin¹,

Leggett²,

Ritchie³

et al. 2018

DDDT

View full text Add to dashboard Cite

IntroductionRosuvastatin reduces concentrations of total cholesterol (TC) and is used for the management of hypercholesterolemia and prevention of acute coronary syndromes. There are no published reports estimating infant exposure to rosuvastatin through breast milk.PurposeThe aims of this study were to quantify concentrations of rosuvastatin in human milk and plasma from a lactating woman taking rosuvastatin and to investigate potential infant exposure.Materials and methodsA 38-year-old breastfeeding mother was commenced on rosuvastatin 20 mg daily for secondary prevention of an acute coronary syndrome. Eight maternal breast milk samples and a single plasma sample were collected over a 24-hour period. The samples were quantified using a sensitive liquid chromatography–mass spectrometry (LC-MS/MS) method.ResultsThe average concentration of rosuvastatin in breast milk was 30.84 ng/mL, and a peak concentration of 58.59 ng/mL occurred at 17 hours after oral administration. Although the milk-to-plasma (M/P) ratio was 16.49 at 14 hours, the theoretical infant dosage (TID) and relative infant dose (RID) were 0.005 mg/kg/day and 1.50%, respectively.ConclusionThe findings suggest that only small amounts of rosuvastatin pass into breast milk. Should the maternal condition necessitate treatment, consideration could be given to the use of rosuvastatin during breastfeeding provided the infant is monitored.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Cholesterol and other products of cholesterol synthesis are vital to infant development, and concerns have been raised that the use of statins may disrupt infant lipid metabolism. 3 , 4 …”

Section: Introductionmentioning

confidence: 99%

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations

Lwin¹,

Leggett²,

Ritchie³

et al. 2018

DDDT

View full text Add to dashboard Cite

show abstract

Lipid-Lowering Therapy in Women of Childbearing Age: a Review and Stepwise Clinical Approach

Grant

Snow²,

Kelsey³

et al. 2022

Curr Cardiol Rep

View full text Add to dashboard Cite

References

2022

Breastfeeding

View full text Add to dashboard Cite

Statiner og amming ved familiær hyperkolesterolemi

Cited by 8 publications

References 23 publications

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations

Lipid-Lowering Therapy in Women of Childbearing Age: a Review and Stepwise Clinical Approach

References

Contact Info

Product

Resources

About

Statiner og amming ved familiær hyperkolesterolemi

Cited by 8 publications

References 23 publications

Transfer of rosuvastatin into breast milk: liquid chromatography&ndash;mass spectrometry methodology and clinical recommendations

Transfer of rosuvastatin into breast milk: liquid chromatography&ndash;mass spectrometry methodology and clinical recommendations

Lipid-Lowering Therapy in Women of Childbearing Age: a Review and Stepwise Clinical Approach

References

Contact Info

Product

Resources

About

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations