Statin Therapy Reduces Contrast-Induced Nephropathy: An Analysis of Contemporary Percutaneous Interventions

The Role of Serum Cystatin C in the Early Detection of Contrast-Induced Nephropathy after Coronary Intervention

“…In present study was found a highly significant increment in serum creatinine and cystatin C while decrease in eGFR 24 hours after angiography (p<0.001, 0.01) when compared between two groups (CIN+, CIN-). This result is consistent with Wang et al, Liu et al and Nozue et al founded serum level of cystatin C is a reliable marker for CIN at 24 hours p<0.001 and serum creatinine increased significantly at 48 hours, also study carried by Wacker-Gussmann et al [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] found that cystatin C level and the cystatin C/creatinine ratio independently predict the risk of CIN in patients undergoing coronary angiography, but another study by Ribichini et al [32] found a significant increase in serum cystatin C concentrations 12 hours earlier than serum creatinine, therefore a rise of serum cystatin C at 12 hours from baseline was the earliest predictor of CIN than serum creatinine [18].…”

“…Although several studies have revealed that serum cystatin C cut off level >1.2 or >1.18 or >1.3 mg/l, 94% sensitivity and 48% specificity is more accurate for diagnostic CIN than serum creatinine [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. While study obtained by Ribichini et al found that absolute changes in serum creatinine proved more accurate than serum cystatin C for predicting CIN at an early stage 12 hours after angiography [18].…”

Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version

“…Because statins exert many different actions, including anti-oxidant and anti-inflammatory actions [155], they are expected to be effective in preventing CIN. Observational studies have reported that statins may preserve kidney function [156,157]. However, meta-analyses have yielded inconsistent conclusions.…”

Contrast-Induced Nephropathy in Patients with Type 2 Diabetes Mellitus and Coronary Artery Disease: Update and Practical Clinical Applications

“…Recent research suggests that 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors, or statins, may reduce the risk of CIN because they have beneficial effects on endothelial function, maintain nitric oxide production and reduce oxidative stress (Adel et al, 2010). Recent retrospective reviews of patients with renal impairment undergoing angiography suggests that the risk of CIN was lower in patients in whom a statin was initiated before the procedure (Khanal et al, 2005). These findings reinforce the rationale for the introduction of statin therapy before undergoing diagnostic or interventional coronary angiography, particularly in patients with type 2 diabetes mellitus (Attallah et al, 2004).…”