Statin Therapy Improves Outcomes After Valvular Heart Surgery

Fedoruk, Lynn M.; Wang, Hongkun; Conaway, Mark R.; Krön, Irving L.; Johnston, Karen C.

doi:10.1016/j.athoracsur.2008.01.078

Cited by 45 publications

(30 citation statements)

References 28 publications

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“…Additional five studies were identified from reference lists of the identified articles and from other databases. Of the 56 potentially relevant articles, 32 were excluded for reasons given in Figure , leaving a total of 24 studies that met the inclusion criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty one studies reported associations between use of statins and AKI, and 14 studies reported associations between use of statins and AKI requiring RRT. Five studies used RCT design, and the rest applied a cohort design . Only one RCT defined AKI as the primary endpoint.…”

Section: Resultsmentioning

confidence: 99%

“…There are also animal studies showing that administration of statins before ischaemic reperfusion insult can reduce the incidence of AKI . However, several randomized studies and observational studies elicited inconsistent results regarding the role of preoperative statins in the prevention of postoperative AKI.…”

mentioning

confidence: 99%

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Effect of preoperative statin therapy on postoperative acute kidney injury in patients undergoing major surgery: Systemic review and meta‐analysis

Pan

Huang

et al. 2014

Nephrology

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This meta-anlaysis shows that preoperative statin therapy is associated with a reduced risk for postoperative AKI. The conclusion is weakened by the heterogeneity of studies, suggesting the need for proper studies. ABSTRACT:We aimed to examine the association between preoperative use of statins and postoperative acute kidney injury (AKI) in patients undergoing major surgery by performing a systemic review and meta-analysis. MEDLINE and EMBASE, from inception to April 2013, and the reference lists of related articles were searched for relevant studies. Trials comparing preoperative statin therapy with no preoperative statin in patients undergoing major surgery were included. Outcome measures of interest were the risk of cumulative postoperative AKI and postoperative AKI requiring renal replacement therapy (RRT). Fixed or random effect meta-analysis was performed to derive summary effect estimates. In five randomized controlled trials (RCTs) and 19 observational studies, comprising a total of 989 173 patients undergoing major surgery, 112 840 patients (11.41%) received preoperative statin therapy. The specific type, dosage, and duration of statin therapy were not available in most studies. Preoperative statin therapy was associated with a significant risk reduction for cumulative postoperative AKI (weighted summary odds ratio (OR) 0.87, 95% CI 0.79 to 0.95). The effect of risk reduction was also significant when considering postoperative AKI requiring RRT (OR 0.80, 95% CI 0.72 to 0.90). When restricting the analysis to the five RCTs, preoperative statin therapy did not show significant protective effect on postoperative AKI (OR 0.49, 95% CI 0.22 to 1.09). In patients undergoing major surgery, preoperative statin therapy could associate with a reduced risk for postoperative AKI. However, considerable heterogeneity existed among included studies. Future randomized trials were warranted for this critical clinical question.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effect of preoperative statin therapy on postoperative acute kidney injury in patients undergoing major surgery: Systemic review and meta‐analysis

Pan

Huang

et al. 2014

Nephrology

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“…There are studies suggesting statin-therapy for every patient with aortic stenosis. (Fedoruk et al 2008) However Rossebo et al showed that statin-therapy did not reduce the composite outcome of combined aortic-valve events and ischemic events in AS patients. Statin-therapy resulted in reduced incidence of ischemic cardiovascular events but not events related to aortic-valve stenosis.…”

Section: Statinsmentioning

confidence: 99%

Aortic Valve Surgery and Reduced Ventricular Function

Wiedemann¹,

Bonaros²,

Kocher³

2011

Aortic Valve Surgery

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“…Furthermore, statin therapy was associated with reduced total and cardiovascular mortality after valvular heart surgery 10) or coronary artery bypass grafting surgery 11) . However, these studies included patients with and without diabetes.…”

Section: Fig 2 Survival Curves (Cardiac Death) Of Patients With Andmentioning

confidence: 99%

Long-Term Efficacy of Pravastatin Therapy in Diabetic Patients Undergoing Complete Coronary Revascularization

Aihara

Miyauchi

Kasai

et al. 2010

JAT

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Aim:The long-term effect of statin therapy in diabetic patients after coronary revascularization is not well established. Accordingly, we sought to determine if whether statin therapy initiated at the time of complete revascularization including percutaneous coronary intervention (PCI) and/or bypass surgery reduces total and cardiac mortality among diabetic patients. Methods: We collected data from 1,138 consecutive patients who underwent complete revascularization (PCI and/or bypass surgery). We then compared all-cause and cardiac mortality rates in 499 patients with diabetes mellitus of whom 149 (29.9%) were treated with statin at the time of revascularization. To adjust the variables that would have been related to the decision regarding statin administration, a propensity score was computed and multivariate Cox regression was carried out.

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Statin Therapy Improves Outcomes After Valvular Heart Surgery

Cited by 45 publications

References 28 publications

Effect of preoperative statin therapy on postoperative acute kidney injury in patients undergoing major surgery: Systemic review and meta‐analysis

Effect of preoperative statin therapy on postoperative acute kidney injury in patients undergoing major surgery: Systemic review and meta‐analysis

Aortic Valve Surgery and Reduced Ventricular Function

Long-Term Efficacy of Pravastatin Therapy in Diabetic Patients Undergoing Complete Coronary Revascularization

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