Statin pretreatment combined with intravenous thrombolysis for ischemic stroke patients: A meta-analysis

Cui, Chaohua; Li, Qiang; Li, Changhong; Zhao, Shubin; Li, Yuchuan

doi:10.1016/j.jocn.2022.02.012

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…In this study, notable differences were observed in diastolic pressure, systolic pressure, fasting blood glucose, and glycosylated hemoglobin between the occurrence group and the nonoccurrence group ( P < 0.05) and diastolic pressure, fasting blood glucose, and glycosylated hemoglobin were identified as the influencing factors of recurrent stroke in young and middle-aged stroke patients after interventional therapy. According to Cui et al, hyperglycemia is an independent risk factor for the recurrence of ischemic stroke with a relative risk of 5.6 [ 18 ]. The reason is that hyperglycemia can accelerate the generation frequency of oxygen free radicals and aggravate endothelial barrier damage [ 19 , 20 ], thus leading to recurrent stroke.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Recurrent Stroke in Young and Middle-Aged Stroke Patients after Interventional Therapy

Dai

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the risk factors of recurrent stroke in young and middle-aged stroke patients after interventional therapy. Methods. Retrospective analysis was conducted on the data of 300 young and middle-aged stroke patients treated in our hospital (February 2015–February 2017). All patients received interventional therapy. They were followed up continuously after the interventional therapy, with recurrent stroke as the only endpoint event, and those who did not have the endpoint events were followed up for 5 years. Then, the patients were divided into the occurrence group and the nonoccurrence group according to whether there was a stroke. The social demographic data and clinical examination data of all patients were collected to analyze the differences between the groups. Logistic regression analysis was performed on the factors with statistically significant differences to verify the factors affecting recurrent stroke in young and middle-aged stroke patients after interventional therapy. Results. Among the 300 patients, 69 (23.0%) had recurrent stroke and 231 (77.0%) had no recurrent stroke. The occurrence group ( n = 69 ) had 12 cases (17.4%) of massive cerebral infarction, 18 cases (26.1%) of cerebral watershed infarction, 5 cases (7.2%) of multiple cerebral infarction, 25 cases (36.2%) of lacunar infarction, and 9 cases (13.0%) of TIA. Notable differences were observed in age, drinking history, marital status, body weight, diastolic pressure, systolic pressure, fasting blood glucose, glycosylated hemoglobin, cholesterol, and fibrinogen between the occurrence group and the nonoccurrence group ( P < 0.05 ). The binary logistic regression analysis showed that age, drinking history, diastolic pressure, fasting blood glucose, glycosylated hemoglobin, cholesterol, and fibrinogen were the influencing factors of recurrent stroke in young and middle-aged stroke patients after interventional therapy. Conclusion. Blood glucose, blood lipid, blood pressure, age, and living habits have an impact on recurrent stroke in young and middle-aged patients after interventional therapy. Therefore, while strictly controlling blood glucose, blood lipid, and blood pressure, patients should improve their living habits and enhance the awareness of prevention after interventional therapy.

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Section: Discussionmentioning

confidence: 99%

Risk Factors of Recurrent Stroke in Young and Middle-Aged Stroke Patients after Interventional Therapy

Dai

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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The Association between Statins Intake and Risk of Post Stroke Pneumonia: A Systematic Review and Meta-Analysis

Darvishi,

Amiri,

Heidari-Soureshjani

et al. 2024

CRCEP

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Aim: This research aimed to examine the relationship between the intake of statins and the risk of post-stroke pneumonia in a systematic review and meta-analysis study. Methods: An extensive search of published articles on March 21st , 2023, was done in several databases, like Web of Science (ISI), PubMed, Cochrane Library, Embase, Scopus, and Google Scholar. The Newcastle Ottawa Scale (NOS) checklist was employed to evaluate the quality of observational studies. Statistical tests (Chi-square test and I2 ) and graphical techniques (Forest plot) were used to determine whether heterogeneity existed in the meta-analysis studies. Funnel plots and Begg and Egger's tests were used to assess the publication bias. Results: Seven studies (5 cohort and 2 case-control studies) were retrieved to examine the association between statins and post-stroke pneumonia. The sample size of the studies compiled in the meta-analysis was obtained to be 68,966 participants. Meta-analysis demonstrated that the overall odds of post-stroke pneumonia in the statin group was equal to 0.87 (95% CI: 0.67 – 1.13; p-value 0.458). Subgroup analysis indicated that the odds of post-stroke pneumonia in the statin group was equal to 0.93 (95% CI: 0.73-1.18; p-value=0.558) in the cohort studies, and equal to 0.92 (95% CI: 0.37-2.26; p-value=0.857) in the case-control studies. The examination of the association between the intake of statins and post-stroke pneumonia showed no evidence of publication bias (Begg's test, p-value = 0.368; Eggers test, p-value = 0.282). Conclusion: In this study, no relationship has been observed between receiving statins and the risk of post-stroke pneumonia.

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Statin pretreatment combined with intravenous thrombolysis for ischemic stroke patients: A meta-analysis

Cited by 2 publications

References 27 publications

Risk Factors of Recurrent Stroke in Young and Middle-Aged Stroke Patients after Interventional Therapy

Risk Factors of Recurrent Stroke in Young and Middle-Aged Stroke Patients after Interventional Therapy

The Association between Statins Intake and Risk of Post Stroke Pneumonia: A Systematic Review and Meta-Analysis

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