Statin combined with exercise training is more effective to improve functional status in dyslipidemic older adults

Baptista, Luís F.; Veríssimo, Manuel Teixeira; Martins, Raul A.

doi:10.1111/sms.13284

Cited by 13 publications

(5 citation statements)

References 32 publications

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“…Namun, olahraga dan aktivitas fisik dinilai dapat menjadi pilihan yang efektif untuk individu yang mengalami peningkatan kolesterol darah 16,17 . Hal ini juga dinyatakan pada penelitian yang menunjukkan bahwa kombinasi statin dan olahraga lebih efektif dalam mengelola kadar kolesterol pada subjek lansia dengan dislipidemia dibandingkan monoterapi statin saja 18 . Penurunan kadar LDL akibat pengaruh olahraga telah dikaitkan dengan efek penurunan kadar Proprotein Convertase Subtilisin/Kexin Type 9 (PSCK9) yang memainkan peranan penting dalam regulasi reseptor LDL 19,20 .…”

Section: Pendahuluanunclassified

Review: Perbaikan Profil Lipid Dengan Pemilihan Olahraga Yang Tepat Berdasarkan Kondisi Individu

Rachman,

Fitri Kusuma,

Pelana

2023

Jurnal Kesehatan Masyarakat

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Diseases related to lipid metabolism continue to be a worldwide concern. Abnormal levels of lipids, especially Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) can cause cardiovascular diseases such as heart attacks and strokes. Until now, these two diseases are the main causes of death globally according to the World Health Organization (WHO). In addition to pharmacological therapy such as statins, lipid levels can also be lowered through exercise. Therefore, this review article aims to provide information about the types of exercise that can reduce blood lipid levels according to the conditions of individual groups in terms of age, gender, and other special groups based on certain disease conditions. It was found that the most widely practiced exercise in all individual groups was aerobic exercise. This exercise is suitable for pregnant and postmenopausal women. Concurrent training is also appropriate for postmenopausal women. Whereas in premenopausal women, water exercise is more effective than concurrent training. In adult men, an effective exercise to do is the nordic walk. In the elderly, exercise that can be done is stationary cycling with one leg at high intensity. Patients with special conditions with Autistic Spectrum Disorder (ASD) can perform coordination and strength exercises. As for Multiple Sclerosis (MS) patients, the exercises that can be done are walking/running and high-intensity resistance training. The application of the type of exercise according to individual conditions can effectively prevent the increase in lipid levels.

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Section: Pendahuluanunclassified

Review: Perbaikan Profil Lipid Dengan Pemilihan Olahraga Yang Tepat Berdasarkan Kondisi Individu

Rachman,

Fitri Kusuma,

Pelana

2023

Jurnal Kesehatan Masyarakat

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“…Despite the widespread use of other lipid-lowering drugs, such as targeted drug therapy for Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9), the morbidity and mortality associated with AS remain high (Schmidt et al, 2017). Current evidence supports the superiority of the combination of exercise and drug therapy over single-drug therapy (Baptista et al, 2018;Gui et al, 2017). Baptista et al demonstrated that the combination of statin and exercise improved dyslipidemia and reduced cardiovascular risk in older adults (Baptista et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Current evidence supports the superiority of the combination of exercise and drug therapy over single-drug therapy (Baptista et al, 2018;Gui et al, 2017). Baptista et al demonstrated that the combination of statin and exercise improved dyslipidemia and reduced cardiovascular risk in older adults (Baptista et al, 2018). However, the International Lipid Expert Panel (ILEP) recently suggested that athletes taking statins are at risk of developing myopathy as well as elevated creatine kinase (CK) (Katsiki et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

A review of the signaling pathways of aerobic and anaerobic exercise on atherosclerosis

Liu

et al. 2023

Journal Cellular Physiology

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Atherosclerosis (AS), a chronic inflammatory vascular disease with lipid metabolism abnormalities, is one of the major pathological bases of coronary heart disease. As people's lifestyles and diets change, the incidence of AS increases yearly. Physical activity and exercise training have recently been identified as effective strategies for lowering cardiovascular disease (CVD) risk. However, the best exercise mode to ameliorate the risk factors related to AS is not clear. The effect of exercise on AS is affected by the type of exercise, intensity, and duration. In particular, aerobic and anaerobic exercise are the two most widely discussed types of exercise. During exercise, the cardiovascular system undergoes physiological changes via various signaling pathways. The review aims to summarize signaling pathways related to AS in two different exercise types and provide new ideas for the prevention and treatment of AS in clinical practice.

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“…These include beneficial effects of physical activity on cholesterol, blood pressure, blood glucose levels, and weight [ 41 ]. While both physical activity and medication adherence demonstrate great benefits in preventing CVD conditions, research has demonstrated that combining statin medication with physical activity can reduce CVD mortality risk more than statin or physical activity alone [ 27 , 29 , 42 , 43 ]. Research has shown that interventions focusing on increasing one positive health behavior may lead to increased levels of engagement in other positive health behaviors [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of a multi-component behavior change technique intervention on medication adherence among individuals on primary prevention statin therapy: a dose-finding protocol

Butler,

Romain,

Augustin

et al. 2023

Trials

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Background In the USA, the primary cause of death and morbidity continues to be cardiovascular disease (CVD). Numerous trials have shown that statin medication reduces the likelihood of CVD events; it is a cornerstone of CVD prevention. However, studies have also indicated that up to 60% of the estimated 26.8 million Americans prescribed primary prevention statin treatment are nonadherent during the first year. Multi-component behavioral change technique (BCT) therapies have shown moderate promise in improving medication adherence as well as other positive health behaviors (such as physical activity). However, no research has looked at the duration of multi-component BCT intervention needed to result in a clinically significant improvement in statin adherence behaviors. This study aims to determine the necessary dose of a multi-component BCT intervention (defined as duration in weeks) to promote adherence to statin medication among those on primary prevention statin treatment by utilizing the modified time-to-event continuous reassessment method (TiTE-CRM). Methods and design The study will utilize the modified TiTE-CRM in 42 participants, recruited in 14 cohorts of 3 participants each. The goal of this analysis is to identify the minimum effective dose (MED) of a multi-behavior change technique (BCT) intervention required to increase adherence to statins by 20% between baseline and follow-up periods. Using the TiTE-CRM method, the dose of the behavior intervention in weeks will be assigned to each cohort based on the performance of the prior cohort. At the end of the study, the intervention dose that has been found to be associated with a 20% increase in statin adherence among 80% of participants assigned to that dose will be identified as the MED. Discussion If successful, the current trial will provide additional guidance to researchers and clinicians seeking to increase statin medication adherence using a BCT intervention by identifying the dose (i.e., the duration) of an intervention required to meaningfully increase adherence. Trial registration ClinicalTrials.gov NCT05273736. Registered on March 10, 2022. https://www.clinicaltrials.gov/ct2/show/NCT05273736

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Statin combined with exercise training is more effective to improve functional status in dyslipidemic older adults

Cited by 13 publications

References 32 publications

Review: Perbaikan Profil Lipid Dengan Pemilihan Olahraga Yang Tepat Berdasarkan Kondisi Individu

Review: Perbaikan Profil Lipid Dengan Pemilihan Olahraga Yang Tepat Berdasarkan Kondisi Individu

A review of the signaling pathways of aerobic and anaerobic exercise on atherosclerosis

The effect of a multi-component behavior change technique intervention on medication adherence among individuals on primary prevention statin therapy: a dose-finding protocol

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