Statin-Associated Psychiatric Adverse Events: A Case/Non Case Evaluation of an Italian Database of Spontaneous Reporting of Adverse Drug Reactions

Tuccori, Marco; Moretti, Ugo; Lapi, Francesco; Coli, Daniela; Testi, Arianna; Mihalj, Martina; Vannacci, Alfredo; Blandizzi, Corrado; Mugelli, Alessandro; Tacca, M. Del

doi:10.2165/00002018-200730100-00061

Cited by 31 publications

(66 citation statements)

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“…The risk of these unfavorable effects is largely outweighed by marked reduction of cardiovascular events in statin users. Rare manifestations of statin intolerance may be; pulmonary, psychiatric, ophthalmic and amyotropic lateral sclerosis [8][9][10][11][12]. However, due to increasing number of patients taking statins, monitoring for any side effects, intense research to recognize their mechanisms and to identify susceptible patients, as well as rational management of these complications are mandatory to further improve safety of these excellent drugs.…”

Section: Introductionmentioning

confidence: 99%

Clinical Manifestations of Adverse Effects of Statins, Oxidative Stress and Possible Role of Antioxidants in Prevention?

Fedačko¹,

Singh²,

Chaithiraphan³

et al. 2010

TONUTRAJ

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Abstract:Background: There is evidence that statins are potent and effective agents with several pleiotropic effects for treatment of coronary artery disease(CAD). Statin may have adverse effects, if given in higher doses and in combinations.Methods: Internet search till 2009 and discussion with colleagues.Results: Statins are wonder drugs influencing wide range of physiological, biochemical,and biological functions.This list appears to be quite large and includes hypolipidemic, vasodilative, antithrombotic, antioxidant, antiinflammatory, antiproliferative, anticoagulant, agiogenic and bone formation inducing functions. Myopathy is the most frequent side effect of statins and in some cases may have a form of severe rhabdomyolysis. Less common adverse effects include hepatotoxicity, peripheral neuropathy, impaired myocardial contractility and autoimmune diseases. Rare manifestations of statin intolerance may be; pulmonary, psychiatric, ophthalmic and amyotropic lateral sclerosis. The risk of these unfavorable effects is largely outweighed by great reduction of cardiovascular events in statin users. The spectrum of statin-related myopathy ranges from common but clinically benign myalgia to rare but life-threatening rhabdomyolysis. Observational studies suggest that myalgia can occur in up to 10% of persons prescribed statins, whereas rhabdomyolysis continues to be rare. The mechanisms of statin-related myopathy are unclear. The criteria of diagnosis of myopathy do not bother about the symptoms of patients and oxidative stress, in absence of raised muscle enzymes.Coenzyme Q10 and other antioxidants are not considered in the prophylaxis of statin toxicity. Because one study showed no decrease in CoQ in the muscle in presence of toxicity, although several studies indicate a reduction in serum levels. Conclusion:Statins would be used more commonly in near future due to their cholesterol lowering and antiinflammatory effects. There would be a marked increase in the Number of patients with statin toxicity. Several studies have reported a significant reduction in the serum CoQ in patients receiving statins.Such concern has also been expressed by the International College of Cardiology in their meeting in April 2002April and 2005April and 2009, proposing that coenzyme Q10 and other antioxidants should be considered in the prevention as well as treatment of statin intoxication.

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Section: Introductionmentioning

confidence: 99%

Clinical Manifestations of Adverse Effects of Statins, Oxidative Stress and Possible Role of Antioxidants in Prevention?

Fedačko¹,

Singh²,

Chaithiraphan³

et al. 2010

TONUTRAJ

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“…The condition usually improves in 35 days after stopping the treatment. Tuccori et al reported the rare cases of 2 patients who did not regain their senses despite many months of follow-up (1).…”

Section: Discussionmentioning

confidence: 99%

“…Olfactory bundles, trigeminal tracts and taste tracts work concurrently for these senses. Based on this information, it has been suggested that macrolides affect the neuronal transmission in one of these tracts directly, causing simultaneous taste and olfactory loss (1).…”

Section: Discussionmentioning

confidence: 99%

“…Among the drugs commonly indicated for taste and olfactory loss are the terbinafine, fluoroquinolone, protein kinase inhibitors (sunitinib, erlotinib, imatinib etc) in addition to macrolide group (1). Taste disorder is the most commonly seen and equally overlooked side effect of the ACE inhibitors.…”

Section: Discussionmentioning

confidence: 99%

“…They do, however, significantly impair the life quality of the patients. These disorders may decrease the appetite and cause malnutrition severe enough to require hospitalization (1).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Permanent Taste and Smell Disorders Induced by Clarithromycin: A Case Report

Şengeze¹,

Yürekli²,

Koyuncuoğlu³

et al. 2015

tnd

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Sensory Topography of Oral Structures

Bearelly

Cheung

2017

JAMA Otolaryngol Head Neck Surg

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Topography of normal oral cavity and oropharyngeal tactile sensation is organized in accordance to decreasing sensitivity along the anteroposterior trajectory and growth of perceptual intensity at all subsites is log-linear. Cheung-Bearelly monofilaments are accessible, disposable, and consistent esthesiometers. This novel clinical tool is deployable for quantitative sensory function assessment of oral cavity and oropharyngeal structures.

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Statin-Associated Psychiatric Adverse Events: A Case/Non Case Evaluation of an Italian Database of Spontaneous Reporting of Adverse Drug Reactions

Cited by 31 publications

References 1 publication

Clinical Manifestations of Adverse Effects of Statins, Oxidative Stress and Possible Role of Antioxidants in Prevention?

Clinical Manifestations of Adverse Effects of Statins, Oxidative Stress and Possible Role of Antioxidants in Prevention?

Permanent Taste and Smell Disorders Induced by Clarithromycin: A Case Report

Sensory Topography of Oral Structures

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