Statin associated muscle symptoms (SAMS): strategies for prevention, assessment and management

Iatan, Iulia; Mancini, G.B. John; Yeoh, Eunice; Hegele, Robert A.

doi:10.1080/14779072.2023.2215982

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2024

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Cited by 4 publications

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“… 48 Ultimately, management strategies for SAMS involve a patient-centered clinical approach to optimize statin tolerability and improve cardiovascular outcomes. 49 …”

Section: Discussionmentioning

confidence: 99%

The Role of Exercise in Statin-Associated Muscle Symptoms Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Mangone,

Kwon,

Johnson

et al. 2024

Mayo Clinic Proceedings: Innovations, Quality & Outcomes

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“… 48 Ultimately, management strategies for SAMS involve a patient-centered clinical approach to optimize statin tolerability and improve cardiovascular outcomes. 49 …”

Section: Discussionmentioning

confidence: 99%

The Role of Exercise in Statin-Associated Muscle Symptoms Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Mangone,

Kwon,

Johnson

et al. 2024

Mayo Clinic Proceedings: Innovations, Quality & Outcomes

View full text Add to dashboard Cite

Biology of time: The temporal distance between cause and effect

Saido

2024

Alzheimer' S Disease Research Guide

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Statin‐associated muscle symptoms: A comprehensive exploration of epidemiology, pathophysiology, diagnosis, and clinical management strategies

Shah,

Shrestha,

Tseng

et al. 2024

Int J of Rheum Dis

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Statins are the first line of treatment for both primary and secondary prevention of atherosclerotic cardiovascular disease. Despite the positive effects of statins on cardiovascular events, not all patients can use them at an optimized dose. The reason for this is the skeletal muscle side effects, termed statin‐associated muscle symptoms (SAMS). Despite extensive research, the precise pathophysiology of SAMS remains unclear and multiple mechanisms may contribute to this phenomenon. Various therapeutic options are available for the management of SAMS, ranging from rechallenging with the same or a different statin to utilizing non‐statin therapeutic alternatives in patients intolerant to statins. However, the lack of consensus on the definition of SAMS, the absence of a definitive diagnostic test, and lack of a universally accepted management algorithm pose a great challenge in dealing with this entity. This review aims to explore the various pathophysiological mechanisms involved in SAMS and understand the difference between self‐limited toxic myopathy and immune‐mediated myopathy requiring immunomodulatory therapy. The conundrum of statin withdrawal, tapering, and rechallenge in SAMS will also be explored in detail along with the newer non‐statin therapies that are available.

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Statin associated muscle symptoms (SAMS): strategies for prevention, assessment and management

Cited by 4 publications

References 117 publications

The Role of Exercise in Statin-Associated Muscle Symptoms Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The Role of Exercise in Statin-Associated Muscle Symptoms Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Biology of time: The temporal distance between cause and effect

Statin‐associated muscle symptoms: A comprehensive exploration of epidemiology, pathophysiology, diagnosis, and clinical management strategies

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